Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China.
College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Bioorg Chem. 2020 Jun;99:103840. doi: 10.1016/j.bioorg.2020.103840. Epub 2020 Apr 10.
Alkaloids, especially heterocyclic alkaloids, have received remarkable attention due to their intriguing structures and potential pharmacological activities. The marine fungi residing in extreme environmental conditions are among the richest sources of these basic nitrogen-containing compounds. Fungal species belonging to the genus Penicillium have been studied worldwide for their biosynthetic potential for generating bioactive alkaloids. This paper offers a systematic review of the newly reported alkaloids produced by marine-derived Penicillium species over the past five years (covering the literature from the beginning of 2014 through the end of 2018) and describes the structural diversity, biological activities, and plausible biosynthetic pathway of the reported compounds. A total of 106 alkaloids and 81 references are included in this review, which is expected to be beneficial for drug development and biosynthesis in the near future.
生物碱，特别是杂环生物碱，因其结构有趣和潜在的药理活性而受到广泛关注。生活在极端环境条件下的海洋真菌是这些含氮基本化合物的最丰富来源之一。全世界都在研究属于青霉属的真菌，因为它们具有产生生物活性生物碱的生物合成潜力。本文对过去五年中（涵盖 2014 年初至 2018 年底的文献）新报道的海洋来源青霉属物种产生的生物碱进行了系统综述，并描述了所报道化合物的结构多样性、生物活性和可能的生物合成途径。本文共包括 106 种生物碱和 81 篇参考文献，预计对未来药物开发和生物合成具有重要意义。
