He Jian, Lion Ulrich, Sattler Isabel, Gollmick Friedrich A, Grabley Susanne, Cai Jingmin, Meiners Marinus, Schünke Henning, Schaumann Karsten, Dechert Ute, Krohn Michael
Leibniz-Institute for Natural Products Research and Infection Biology, Hans-Knöll-Institute, Beutenbergstrasse 11a, D-07745 Jena, Germany.
J Nat Prod. 2005 Sep;68(9):1397-9. doi: 10.1021/np058018g.
From Penicillium janczewskii, obtained from a marine sample, two new diastereomeric quinolinones, 3S,4R-dihydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (1) and 3R,4R-dihydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (2), were identified, along with two known alkaloids, peniprequinolone (3) and 3-methoxy-4-hydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (4). Cytotoxicity testing on eight tumor cell lines revealed a moderate specificity of 2 on SKOV-3 cells.
从一份海洋样本中分离得到的詹氏青霉中，鉴定出了两种新的非对映体喹啉酮，即3S,4R-二羟基-4-(4'-甲氧基苯基)-3,4-二氢-2(1H)-喹啉酮（1）和3R,4R-二羟基-4-(4'-甲氧基苯基)-3,4-二氢-2(1H)-喹啉酮（2），同时还鉴定出了两种已知生物碱，即青霉前喹啉酮（3）和3-甲氧基-4-羟基-4-(4'-甲氧基苯基)-3,4-二氢-2(1H)-喹啉酮（4）。对八种肿瘤细胞系的细胞毒性测试显示，化合物2对SKOV-3细胞具有中等特异性。
