Integrative Pharmacology and Systems Neuroscience Research Group, IMIM (Hospital del Mar Research Institute), Dr. Aiguader 88, 08003 Barcelona, Spain; UniversitatPompeuFabra (CEXS-UPF), Dr. Aiguader 88, 08003 Barcelona, Spain; CIBER de Fisiopatología Obesidad y Nutrición (CIBEROBN), Santiago de Compostela 15706, Spain.
UniversitatPompeuFabra (CEXS-UPF), Dr. Aiguader 88, 08003 Barcelona, Spain.
Food Chem. 2020 Aug 30;322:126676. doi: 10.1016/j.foodchem.2020.126676. Epub 2020 Mar 27.
To date, pharmacokinetics of maslinic (MA) and oleanolic (OA) acids, at normal dietary intakes in humans, have not been evaluated, and data concerning their bioactive effects are scarce. We assessed MA and OA pharmacokinetics after ingestion of olive oils (OOs) with high and low triterpenic acid contents, and specifically the effect of triterpenes on endothelial function. We performed a double-blind, dose-response, randomized, cross-over nutritional intervention in healthy adults, and observed that MA and OA increased in biological fluids in a dose-dependent manner. MA bioavailability was greater than that of OA, and consumption of pentacyclic triterpenes was associated with improved endothelial function. To the best of our knowledge, this is the first time MA pharmacokinetics, and effects on endothelial function in vivo, have been reported in humans.
迄今为止，尚未评估人体正常饮食摄入时熊果酸（MA）和齐墩果酸（OA）的药代动力学，关于它们的生物活性作用的数据也很少。我们评估了摄入高、低三萜酸含量橄榄油（OO）后 MA 和 OA 的药代动力学，特别是三萜类物质对内皮功能的影响。我们在健康成年人中进行了一项双盲、剂量反应、随机、交叉营养干预研究，观察到 MA 和 OA 在生物体液中呈剂量依赖性增加。MA 的生物利用度大于 OA，并且五环三萜的消耗与内皮功能的改善相关。据我们所知，这是首次在人体中报告 MA 的药代动力学以及对体内内皮功能的影响。
