Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Center, University of Granada, Parque Tecnológico de la Salud, Avenida del Conocimiento s/n, Armilla, 18016 Granada, Spain.
Fundación Pública Andaluza para la Investigación Biosanitaria de Andalucía Oriental "Alejandro Otero" (FIBAO), Avenida de Madrid 15, 18012 Granada, Spain.
Nutrients. 2019 Mar 6;11(3):561. doi: 10.3390/nu11030561.
A regular consumption of virgin olive oil (VOO) is associated with a reduced risk of cardiovascular disease. We aimed to assess whether the raw intake of an optimized VOO (OVOO, 490 ppm of phenolic compounds and 86 ppm of triterpenes), and a functional olive oil (FOO, 487 ppm of phenolic compounds and enriched with 389 ppm of triterpenes) supplementation (30 mL per day) during three weeks would provide additional health benefits to those produced by a standard VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes) on oxidative and inflammatory biomarkers. Fifty-one healthy adults participated in a randomized, crossover, and controlled study. Urinary 8-hidroxy-2'-deoxyguanosine, plasma interleukin-8 (IL-8), and tumor necrosis factor α (TNF- α) concentrations were lower after the intervention with the FOO than after the OVOO ( = 0.033, = 0.011 and = 0.020, respectively). In addition, IL-8 was lower after the intervention with FOO than after VOO intervention ( = 0.002). This study provides a first level of evidence on the in vivo health benefits of olive oil triterpenes (oleanolic and maslinic acids) in healthy humans, decreasing DNA oxidation and plasma inflammatory biomarkers. The trial was registered in ClinicalTrials.gov ID: NCT02520739.
经常食用初榨橄榄油（VOO）可降低心血管疾病的风险。我们旨在评估在三周内，摄入优化的初榨橄榄油（OVOO，含有 490ppm 的酚类化合物和 86ppm 的三萜烯）和功能性橄榄油（FOO，含有 487ppm 的酚类化合物并富含 389ppm 的三萜烯）补充剂（每天 30 毫升）是否会带来除标准 VOO（124ppm 的酚类化合物和 86ppm 的三萜烯）以外的健康益处，对氧化和炎症生物标志物产生影响。51 名健康成年人参与了一项随机、交叉、对照研究。尿液中 8-羟基-2'-脱氧鸟苷、血浆白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF-α）浓度在 FOO 干预后比 OVOO 干预后降低（=0.033，=0.011 和=0.020，分别）。此外，FOO 干预后 IL-8 水平低于 VOO 干预后（=0.002）。这项研究提供了在健康人类中橄榄油三萜（齐墩果酸和马栗树皮酸）具有体内健康益处的初步证据，可降低 DNA 氧化和血浆炎症生物标志物。该试验在 ClinicalTrials.gov 注册号为 NCT02520739。
