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J Biomed Res. 2019 Jul 30;34(2):122-128. doi: 10.7555/JBR.33.20180107.
2
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本文引用的文献

1
[Risk factors for fetal macrosomia in patients without gestational diabetes mellitus].[非妊娠期糖尿病患者胎儿巨大儿的危险因素]
Ginecol Obstet Mex. 2016 Mar;84(3):164-71.
2
The levels of human milk microRNAs and their association with maternal weight characteristics.人乳中微小RNA的水平及其与母亲体重特征的关联。
Eur J Clin Nutr. 2016 Apr;70(4):445-9. doi: 10.1038/ejcn.2015.168. Epub 2015 Oct 21.
3
Transgenic mouse milk expressing human bile salt-stimulated lipase improves the survival and growth status of premature mice.表达人胆汁盐刺激脂肪酶的转基因小鼠乳汁可改善早产小鼠的生存和生长状况。
Mol Biotechnol. 2015 Mar;57(3):287-97. doi: 10.1007/s12033-014-9822-5.
4
rhBSSL improves growth and LCPUFA absorption in preterm infants fed formula or pasteurized breast milk.重组人乳脂肪球膜蛋白改善了用配方奶或巴氏杀菌母乳喂养的早产儿的生长及长链多不饱和脂肪酸吸收。
J Pediatr Gastroenterol Nutr. 2014 Jul;59(1):61-9. doi: 10.1097/MPG.0000000000000365.
5
Bile salt-stimulated lipase plays an unexpected role in arthritis development in rodents.胆盐刺激脂肪酶在啮齿动物关节炎发展中起着意想不到的作用。
PLoS One. 2012;7(10):e47006. doi: 10.1371/journal.pone.0047006. Epub 2012 Oct 11.
6
Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice.母亲在孕期和哺乳期肥胖会导致小鼠后代非酒精性脂肪肝的发生。
J Hepatol. 2010 Jun;52(6):913-20. doi: 10.1016/j.jhep.2009.12.042. Epub 2010 Apr 1.
7
Nutritional programming of the metabolic syndrome.代谢综合征的营养编程。
Nat Rev Endocrinol. 2009 Nov;5(11):604-10. doi: 10.1038/nrendo.2009.195. Epub 2009 Sep 29.
8
Carboxyl ester lipase from either mother's milk or the pancreas is required for efficient dietary triglyceride digestion in suckling mice.哺乳期小鼠高效消化膳食甘油三酯需要母乳或胰腺中的羧基酯酶。
J Nutr. 2008 May;138(5):927-30. doi: 10.1093/jn/138.5.927.
9
Bile salt-dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans.胆汁盐依赖性脂肪酶与血小板CXCR4相互作用并调节小鼠和人类的血栓形成。
J Clin Invest. 2007 Dec;117(12):3708-19. doi: 10.1172/JCI32655.
10
Bile salt-stimulated lipase and pancreatic lipase-related protein 2 are the dominating lipases in neonatal fat digestion in mice and rats.胆汁盐刺激脂肪酶和胰腺脂肪酶相关蛋白2是小鼠和大鼠新生儿脂肪消化中的主要脂肪酶。
Pediatr Res. 2007 Nov;62(5):537-41. doi: 10.1203/PDR.0b013e3181559e75.

中国女性乳汁中胆盐刺激脂肪酶的水平及其与母亲体重指数的关系。

The level of bile salt-stimulated lipase in the milk of Chinese women and its association with maternal BMI.

作者信息

Sha Lijun, Zhou Shanshan, Xi Yangyang, Li Rong, Li Xiaonan

机构信息

Department of Children Health Care, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China.

出版信息

J Biomed Res. 2019 Jul 30;34(2):122-128. doi: 10.7555/JBR.33.20180107.

DOI:10.7555/JBR.33.20180107
PMID:32305966
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7183295/
Abstract

This study aimed to investigate the bile salt-stimulated lipase (BSSL) concentration in the milk of Chinese women and its correlation with maternal body mass index (BMI), gestational diabetes mellitus (GDM) and gestational hypertensive disorder (GHD). The BSSL levels in the milk samples were measured by enzyme-linked immunosorbent assay (ELISA). BSSL level in colostrum milk of mothers with full-term infants was positively correlated with pregnancy week and negatively correlated with maternal pre-pregnancy BMI and BMI late in pregnancy. Moreover, the BSSL concentration in mature milk was positively correlated with BMI gain during pregnancy. The BSSL concentration in colostrum milk was lower in GDM mothers than in normal mothers. The BSSL helps infants digest fat in early life and its level was associated with lactation. The changes in BSSL characteristics with maternal BMI and GDM in this study may have clinical implications regarding the effects of pregnancy weight and metabolism on the nutrition and health of the offspring.

摘要

本研究旨在调查中国女性乳汁中胆盐刺激脂肪酶（BSSL）的浓度及其与产妇体重指数（BMI）、妊娠期糖尿病（GDM）和妊娠期高血压疾病（GHD）的相关性。通过酶联免疫吸附测定（ELISA）法检测乳汁样本中的BSSL水平。足月产母亲初乳中的BSSL水平与孕周呈正相关，与孕前BMI及孕晚期BMI呈负相关。此外，成熟乳中的BSSL浓度与孕期体重增加呈正相关。GDM母亲初乳中的BSSL浓度低于正常母亲。BSSL有助于婴儿在生命早期消化脂肪，其水平与泌乳有关。本研究中BSSL特征随产妇BMI和GDM的变化可能对妊娠体重和代谢对后代营养与健康的影响具有临床意义。