Kokubun M, Fujimoto S, Shrestha R D, Ohta M, Kobayashi K, Kiuchi S, Koike S, Konno C, Takahashi M, Fujita M
1st Dept. of Surgery, School of Med., Chiba Univ.
Gan No Rinsho. 1988 Dec;34(15):2075-8.
To study the relationship between thermotolerance and post-thermal phenomenon, tumor pO2 (TpO2) in xenoplanted gastric cancer tissue (H-23) has been measured by a polarographic method. The heat treatment was done in a water bath at 43.5 +/- 0.1 degrees C for 23 minutes. In order to produce thermotolerance, the second treatment was carried out at an interval of 24 hours, or, alternatively at 72 hours, or at 5 days or at 7 days. The thermotolerance of the H-23 tumor reached its maximum at the 72 hour-interval and was seen to disappear completely at 7 days. The TpO2 in the H-23 tumor decreased immediately after a single heat treatment and returned to its pre-treated value after 10 hours. In cases of the second heat treatment, the 72-hour interval group returned to its pre-treated value in 2-6 hours, whereas the 24-hour, 5-day, and 7-day interval groups showed a longer recovery time. The relationship between thermotolerance and TpO2 recovery was inverse at r = -0.858 and p = 0.035. Thus, our study suggests that not only is the thermotolerance affected by the alteration of the intra-cellular components, but also by the post-thermal changes in the tumor vessels.
为研究耐热性与热后现象之间的关系，采用极谱法测量了异种移植胃癌组织（H - 23）中的肿瘤pO2（TpO2）。热处理在43.5±0.1℃的水浴中进行23分钟。为产生耐热性，第二次处理在24小时、72小时、5天或7天的间隔后进行。H - 23肿瘤的耐热性在72小时间隔时达到最大值，并在7天时完全消失。H - 23肿瘤中的TpO2在单次热处理后立即下降，并在10小时后恢复到处理前的值。在第二次热处理的情况下，72小时间隔组在2 - 6小时内恢复到处理前的值，而24小时、5天和7天间隔组显示出更长的恢复时间。耐热性与TpO2恢复之间的关系呈负相关，r = - 0.858，p = 0.035。因此，我们的研究表明，耐热性不仅受细胞内成分变化的影响，还受肿瘤血管热后变化的影响。
