Fujimoto S, Ohta M, Shrestha R D, Kokubun M, Kobayashi K, Kiuchi S, Konno C, Takahashi M, Fujita M, Taguchi T
First Department of Surgery, School of Medicine, Chiba University, Japan.
Jpn J Surg. 1989 Mar;19(2):203-7. doi: 10.1007/BF02471586.
To compare the thermotolerance in vivo of two human gastric cancers with different doubling times, the xenografted tumors were warmed twice at 43.5 +/- 0.1 degree C in a water bath for 20 minutes at a predetermined interval. In the tumors with doubling times of 5.2 and 10.9 days, a 7-day interval heat treatment resulted in a prolongation in tumor tripling times by 156 per cent and 132 per cent, respectively, compared with a single heat treatment for 40 minutes. On the contrary, two heat treatments given at intervals of 3 to 5 days had a short tumor tripling time, compared to that of the 40-minute single treatment. Thus, the thermotolerance of these human gastric cancers gradually increased to a maximum within a 3- to 4-day interval and disappeared completely after a 7-day interval. These results indicate that the times required to reach maximal thermotolerance in these human gastric cancers were longer than those previously demonstrated for human and rodent cancer cell lines in vitro. The development and decay of thermotolerance in these human gastric cancers need to be considered in the design of multiple-fractionated regimens.
为比较两种倍增时间不同的人胃癌在体内的耐热性，将移植瘤在43.5±0.1摄氏度的水浴中按预定间隔进行两次加热，每次20分钟。对于倍增时间分别为5.2天和10.9天的肿瘤，与单次40分钟热处理相比，7天间隔的热处理使肿瘤三倍增长时间分别延长了156%和132%。相反，与40分钟单次处理相比，间隔3至5天进行的两次热处理使肿瘤三倍增长时间缩短。因此，这些人胃癌的耐热性在3至4天的间隔内逐渐增加至最大值，并在7天间隔后完全消失。这些结果表明，这些人胃癌达到最大耐热性所需的时间比先前在体外对人和啮齿动物癌细胞系所证明的时间更长。在设计多分次治疗方案时，需要考虑这些人胃癌中耐热性的产生和消退。
