Department of Ophthalmology, Eye and ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, PR China.
NHC Key Laboratory of Myopia (Fudan University); Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China.
BMC Ophthalmol. 2020 Apr 19;20(1):158. doi: 10.1186/s12886-020-01432-x.
To evaluate lenticule surface characteristics of small incision lenticule extraction (SMILE) for hyperopia correction in rabbits.
The left and right eyes of 8 rabbits were divided into two groups. The right eyes were assigned to a myopia group, and the left eyes to a hyperopia group. The rabbits received SMILE procedures with + 3.00 D and - 3.00 D correction for the hyperopia and myopia groups, respectively. Extracted lenticules were examined via scanning electron microscopy. Lenticules from odd-numbered rabbits were accessed with the anterior surface, and lenticules from even-numbered rabbits were observed with the posterior surface. A previously established scoring system was used to evaluate lenticule surface characteristics. Statistical analysis was conducted to compare the scores between the two groups.
All procedures were performed successfully, and the lenticules were extracted smoothly. One myopia lenticule that was facing downward was handled failed in preparation for imaging, thus 15 lenticules were ultimately graded. Twelve lenticules exhibited smooth surfaces, and regularly arranged tissue bridges were observed in almost all regions. Three lenticules exhibited a partially rough surface and irregularities affecting more than 10% of the lenticules (2 in the hyperopia group and 1 in the myopia group). Rough lenticules occurred in twice as many lenticules in the hyperopia group compared to the myopia group.
Scan quality of lenticules after SMILE for hyperopia correction is comparable to that of myopia lenticules. The shape of hyperopic lenticule may increase the difficulty of surgical manipulation and result in surface roughness.
评估小切口微透镜切除术（SMILE）治疗远视矫正的透镜表面特性。
8 只兔子的左眼和右眼分为两组。右眼为近视组，左眼为远视组。兔子接受 SMILE 手术，右眼接受+3.00 D 矫正，左眼接受-3.00 D 矫正。通过扫描电子显微镜检查提取的透镜。奇数号兔子的透镜从前表面进入，偶数号兔子的透镜从后表面观察。使用先前建立的评分系统评估透镜表面特征。对两组之间的评分进行统计分析。
所有手术均顺利完成，透镜顺利提取。有 1 个近视透镜因准备成像而朝下，故处理失败，最终有 15 个透镜进行分级。12 个透镜表面光滑，几乎所有区域都观察到规则排列的组织桥。3 个透镜表面部分粗糙，不规则影响超过 10%的透镜（2 个在远视组，1 个在近视组）。与近视组相比，远视组的粗糙透镜数量是其两倍。
SMILE 治疗远视矫正后的透镜扫描质量与近视透镜相当。远视透镜的形状可能会增加手术操作的难度，并导致表面粗糙度。
