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Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19).拯救脓毒症运动:2019 冠状病毒病(COVID-19)危重症成人管理指南。
Intensive Care Med. 2020 May;46(5):854-887. doi: 10.1007/s00134-020-06022-5. Epub 2020 Mar 28.
2
Management of Critically Ill Adults With COVID-19.新型冠状病毒肺炎危重症成人患者的管理
JAMA. 2020 May 12;323(18):1839-1841. doi: 10.1001/jama.2020.4914.
3
A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.洛匹那韦-利托那韦治疗成人重症 COVID-19 患者的临床试验。
N Engl J Med. 2020 May 7;382(19):1787-1799. doi: 10.1056/NEJMoa2001282. Epub 2020 Mar 18.
4
Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1.与严重急性呼吸综合征冠状病毒1(SARS-CoV-1)相比,严重急性呼吸综合征冠状病毒2(SARS-CoV-2)在气溶胶和表面的稳定性
N Engl J Med. 2020 Apr 16;382(16):1564-1567. doi: 10.1056/NEJMc2004973. Epub 2020 Mar 17.
5
[Consideration and prevention of the aerosol transmission of 2019 novel coronavirus].[2019新型冠状病毒气溶胶传播的考量与预防]
Zhonghua Yan Ke Za Zhi. 2020 Sep 11;56(9):653-656. doi: 10.3760/cma.j.cn112142-20200313-00181.
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In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).羟氯喹治疗严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2)的体外抗病毒活性和优化剂量设计预测。
Clin Infect Dis. 2020 Jul 28;71(15):732-739. doi: 10.1093/cid/ciaa237.
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[Advances in the research of mechanism and related immunotherapy on the cytokine storm induced by coronavirus disease 2019].[新型冠状病毒肺炎细胞因子风暴的机制及相关免疫治疗研究进展]
Zhonghua Shao Shang Za Zhi. 2020 Jun 20;36(6):471-475. doi: 10.3760/cma.j.cn501120-20200224-00088.
8
Convalescent plasma as a potential therapy for COVID-19.康复期血浆作为治疗新冠肺炎的一种潜在疗法。
Lancet Infect Dis. 2020 Apr;20(4):398-400. doi: 10.1016/S1473-3099(20)30141-9. Epub 2020 Feb 27.
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Clinical characteristics of hospitalized patients with SARS-CoV-2 infection: A single arm meta-analysis.住院的 SARS-CoV-2 感染患者的临床特征:一项单臂荟萃分析。
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High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa.2019-nCoV 对口腔黏膜上皮细胞 ACE2 受体的高表达。
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新型冠状病毒肺炎危重症患者的治疗策略

Therapeutic strategies for critically ill patients with COVID-19.

作者信息

Li Lei, Li Ranran, Wu Zhixiong, Yang Xianghong, Zhao Mingyan, Liu Jiao, Chen Dechang

机构信息

Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.

Department of Surgical Intensive Care Unit, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People's Republic of China.

出版信息

Ann Intensive Care. 2020 Apr 20;10(1):45. doi: 10.1186/s13613-020-00661-z.

DOI:10.1186/s13613-020-00661-z
PMID:32307593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7167303/
Abstract

Since the 2019 novel coronavirus disease (COVID-19) outbreak originated from Wuhan, Hubei Province, China, at the end of 2019, it has become a clinical threat to the general population worldwide. Among people infected with the novel coronavirus (2019-nCoV), the intensive management of the critically ill patients in intensive care unit (ICU) needs substantial medical resource. In the present article, we have summarized the promising drugs, adjunctive agents, respiratory supportive strategies, as well as circulation management, multiple organ function monitoring and appropriate nutritional strategies for the treatment of COVID-19 in the ICU based on the previous experience of treating other viral infections and influenza. These treatments are referable before the vaccine and specific drugs are available for COVID-19.

摘要

自2019年新型冠状病毒病(COVID-19)于2019年底在中国湖北省武汉市爆发以来,它已成为全球普通人群面临的临床威胁。在新型冠状病毒(2019-nCoV)感染者中,重症监护病房(ICU)对危重症患者的强化管理需要大量医疗资源。在本文中,我们基于以往治疗其他病毒感染和流感的经验,总结了用于ICU中治疗COVID-19的有前景的药物、辅助药物、呼吸支持策略、循环管理、多器官功能监测以及适当的营养策略。在有针对COVID-19的疫苗和特效药物之前,这些治疗方法具有参考价值。