Hemida Aiat Shaban, Hammam Mostafa Ahmed, Salman Arwa Tawfik Ahmed, Shehata Wafaa Ahmed
Pathology Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt.
Dermatology Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt.
J Cosmet Dermatol. 2020 Dec;19(12):3395-3402. doi: 10.1111/jocd.13425. Epub 2020 Apr 19.
Psoriasis is an inflammatory disease that is mostly immune-derived. It causes proliferation of skin cells, forming plaques. Psoriasis etiology is unknown. It might be multifactorial.
This work aimed to study Smad7 expression in psoriasis vulgaris patients in comparison with normal skin.
PATIENTS/METHODS: Thirty patients with psoriasis vulgaris in comparison with 20 age- and sex-matched seemingly healthy individuals were selected. We used psoriasis area and severity index (PASI) to evaluate psoriasis severity. Skin biopsies were prepared from skin lesions (30), perilesions (30) and control (20) groups for histopathological and immunostaining evaluation of Smad7.
Smad7 was progressively upregulated in proliferating keratinocytes from controls (58.18 ± 30.93) to perilesional (106 ± 38.93) and lesional (156.33 ± 62.01) skin (P < .001). Also, dermal inflammatory cells showed upregulation of Smad7 expression from control skin (40 ± 28.28) to skin lesions (137.33 ± 73.86) (P < .010). Smad7 expression showed a positive significant correlation with psoriasis severity (r = .452; P < .012).
Smad7 may be involved in increased keratinocyte proliferation as well as skin inflammation in psoriasis vulgaris patients.
银屑病是一种主要由免疫因素引起的炎症性疾病。它会导致皮肤细胞增殖，形成斑块。银屑病的病因尚不清楚，可能是多因素的。
本研究旨在比较寻常型银屑病患者与正常皮肤中Smad7的表达情况。
患者/方法：选取30例寻常型银屑病患者，并与20例年龄和性别匹配的看似健康的个体进行比较。我们使用银屑病面积和严重程度指数（PASI）来评估银屑病的严重程度。从皮损组（30例）、皮损周围组（30例）和对照组（20例）制备皮肤活检样本，用于对Smad7进行组织病理学和免疫染色评估。
Smad7在从对照组（58.18±30.93）到皮损周围组（106±38.93）和皮损组（156.33±62.01）的增殖角质形成细胞中逐渐上调（P<.001）。此外，真皮炎症细胞中Smad7的表达也从对照皮肤（40±28.28）上调至皮肤病变处（137.33±73.86）（P<.010）。Smad7的表达与银屑病严重程度呈显著正相关（r =.452；P<.012）。
Smad7可能参与了寻常型银屑病患者角质形成细胞增殖增加以及皮肤炎症过程。
