Department of Cardiology, Montpellier University Hospital, 34295, Montpellier, Cedex 5, France.
PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295, Montpellier, Cedex 5, France.
ESC Heart Fail. 2020 Jun;7(3):1025-1030. doi: 10.1002/ehf2.12721. Epub 2020 Apr 19.
Intra-aortic balloon pump (IABP) utilization was expected to be quickly abandoned following the IABP-shock trial and its class III, level B recommendation in the 2016 European Society of Cardiology (ESC) guidelines. The aim of this study was to evaluate the use of IABP compared with other mechanical support devices in a nationwide approach.
We conducted a retrospective study based on the French national hospital discharge database. All patients undergoing assist device implantation by IABP, extracorporeal membrane oxygenation (ECMO), or IMPELLA® from 2014 to 2018 (2 years before/2 years after the 2016 guidelines) were included. The primary endpoint was the incidence of IABP implantation over the years. Secondary endpoints were incidence of total assist device, ECMO, and IMPELLA® implantations. From 2014 to 2018, a total of 18 940 patients benefited from mechanical support by IABP (n = 6657, 35.2%), ECMO (n = 11 881, 62.7%), or IMPELLA® (n = 402, 2.1%) in France. The incidence of total mechanical support implantations (ECMO and IABP) was constant over the years. IABP implantations decreased progressively from 1725 implantations in 2014 to 996 in 2018 (-42%). By contrast, ECMO implantations increased progressively from 1919 implantations in 2014 to 2763 implantations in 2018 (+44%). IMPELLA® implantations remained stable over the years from 63 (1.7%) implantations in 2014 to 83 (2.1%) in 2018.
In this nationwide real-life study, despite a significant decline in IABP implantations over the years since the ESC guidelines, this device remained used in clinical practice with around 1000 implantations in 2018. The size of centres was not strictly correlated with this use, suggesting differential uses depending on the local background.
在 IABP-shock 试验及其 2016 年欧洲心脏病学会 (ESC) 指南的 III 类、B 级推荐之后,预计主动脉内球囊泵 (IABP) 的使用将很快被摒弃。本研究旨在通过全国性方法评估与其他机械支持设备相比,IABP 的使用情况。
我们进行了一项基于法国全国医院出院数据库的回顾性研究。纳入 2014 年至 2018 年期间(2016 年指南发布前/后各 2 年)接受 IABP、体外膜肺氧合 (ECMO) 或 IMPELLA® 辅助装置植入的所有患者。主要终点是多年来 IABP 植入的发生率。次要终点是总辅助装置、ECMO 和 IMPELLA® 植入的发生率。2014 年至 2018 年,法国共有 18940 例患者接受 IABP(n=6657,35.2%)、ECMO(n=11881,62.7%)或 IMPELLA®(n=402,2.1%)的机械支持。总机械支持植入物(ECMO 和 IABP)的发生率多年来保持不变。IABP 植入物从 2014 年的 1725 例逐渐减少至 2018 年的 996 例(-42%)。相比之下,ECMO 植入物从 2014 年的 1919 例逐渐增加至 2018 年的 2763 例(+44%)。IMPELLA®植入物多年来保持稳定,从 2014 年的 63 例(1.7%)增加至 2018 年的 83 例(2.1%)。
在这项全国范围内的真实研究中,尽管自 ESC 指南发布以来,IABP 的植入数量多年来显著下降,但该设备仍在临床实践中使用,2018 年约有 1000 例植入。中心的规模与这种使用并没有严格的相关性,这表明根据当地情况存在不同的使用方式。