Swetha Dara Lakshmi, Vinay C, Uloopi K S, RojaRamya Kakarla Sri, Chandrasekhar Rayala
Department of Pedodontics and Preventive Dentistry, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India.
Contemp Clin Dent. 2019 Jul-Sep;10(3):477-482. doi: 10.4103/ccd.ccd_805_18.
Pit and fissure sealants (PFSs) are the most effective preventive materials in dentistry. Secondary caries around the sealed pits and fissures at the material-tooth interface and the wear of the material remains the common problems. To address these problems, efforts have been made by incorporating zinc oxide (ZnO) and calcium fluoride (CaF) nanoparticles (NPs) into the sealants to develop caries-inhibiting and stress-bearing sealants.
Evaluation of antibacterial and mechanical properties of PFS containing ZnO and CaF NPs.
This was an study.
A total of 196 fissure sealant samples were divided into six test groups and a control group. The test group samples were prepared by incorporating two concentrations (0.5 wt% and 1 wt%) of ZnO and CaF NPs into the sealants. The antibacterial activity was evaluated by direct contact test; compressive and flexural strengths were evaluated by a universal testing machine.
Statistical analysis was done by one-way ANOVA and Tukey test.
Sealants containing 1 wt% ZnO and CaF NPs and their mixture exhibited significantly higher antibacterial activity against and when compared to control group ( < 0.001). Samples with ZnO NPs exhibited similar mechanical properties as conventional sealant (control group); however, the samples with CaF NPs showed inferior mechanical properties ( < 0.05).
The observations of the study infer that sealants containing 1 wt% ZnO and CaF NPs and their mixture exhibited superior antibacterial activity. The mechanical properties of samples containing ZnO and mixture of ZnO and CaF particles remained comparable to the conventional sealants.
窝沟封闭剂（PFSs）是牙科领域最有效的预防材料。封闭剂与牙齿界面处窝沟周围的继发龋以及材料磨损仍是常见问题。为解决这些问题，人们已致力于将氧化锌（ZnO）和氟化钙（CaF）纳米颗粒（NPs）加入封闭剂中，以开发具有防龋和抗压性能的封闭剂。
评估含ZnO和CaF NPs的窝沟封闭剂的抗菌性能和力学性能。
这是一项……研究。
总共196个窝沟封闭剂样本被分为六个试验组和一个对照组。试验组样本通过将两种浓度（0.5 wt%和1 wt%）的ZnO和CaF NPs加入封闭剂中制备而成。通过直接接触试验评估抗菌活性；通过万能试验机评估压缩强度和弯曲强度。
采用单因素方差分析和Tukey检验进行统计分析。
与对照组相比，含1 wt% ZnO和CaF NPs及其混合物的封闭剂对……和……表现出显著更高的抗菌活性（P < 0.001）。含ZnO NPs的样本表现出与传统封闭剂（对照组）相似的力学性能；然而，含CaF NPs的样本力学性能较差（P < 0.05）。
该研究的观察结果表明，含1 wt% ZnO和CaF NPs及其混合物的封闭剂具有卓越的抗菌活性。含ZnO以及ZnO与CaF颗粒混合物的样本的力学性能与传统封闭剂相当。
