Choi Ji-Won, Han A Ruem, Yang Song-Yi
Department of Dental Hygiene, Kyungdong University, Wonju-si 26495, Republic of Korea.
Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, Seoul 03722, Republic of Korea.
Polymers (Basel). 2024 Jun 28;16(13):1855. doi: 10.3390/polym16131855.
The purpose of this study was to evaluate a resin based pit and fissure sealant containing 45S5 bioactive glass (BAG) by examining its ion release, pH variation, and apatite-forming properties. To prepare the experimental materials, 45S5 BAG, used as a filler, was incorporated into the light curable resin matrix at concentrations of 0 (control), 12.5, 37.5, and 50.0 wt.%. Ion release, pH variation, and apatite formation (Raman spectrometer and scanning electron microscopy-energy-dispersive X-ray spectrometry measurements) were performed. While no ions were released from the control group, the experimental groups containing 45S5 BAG showed an increased release of Ca and P ions with increasing amounts of 45S5 BAG ( < 0.05). The pH of the experimental group remained high and was significantly different from the control group ( < 0.05). Unlike the control group, it was confirmed that the apatite peak was formed in the 50.0 wt.% BAG group for 90 days, and the apatite layer consisting of Ca and P was deposited on the surface. Thus, a resin based pit and fissure sealant containing 45S5 BAG is a promising material for preventing secondary caries by releasing ions and forming apatite.
本研究的目的是通过检测含45S5生物活性玻璃（BAG）的树脂基窝沟封闭剂的离子释放、pH值变化和磷灰石形成特性，对其进行评估。为制备实验材料，将用作填料的45S5 BAG以0（对照）、12.5、37.5和50.0 wt.%的浓度掺入光固化树脂基质中。进行了离子释放、pH值变化和磷灰石形成（拉曼光谱仪和扫描电子显微镜-能量色散X射线光谱测量）实验。对照组未释放离子，而含45S5 BAG的实验组随着45S5 BAG含量的增加，Ca和P离子的释放量增加（<0.05）。实验组的pH值保持较高水平，与对照组有显著差异（<0.05）。与对照组不同，在50.0 wt.% BAG组中，90天时证实形成了磷灰石峰，且表面沉积了由Ca和P组成的磷灰石层。因此，含45S5 BAG的树脂基窝沟封闭剂是一种通过释放离子和形成磷灰石来预防继发龋的有前景的材料。
