Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, People's Republic of China.
College of Chemistry, Nanchang University, Nanchang 330038, People's Republic of China.
Int J Nanomedicine. 2020 Apr 1;15:2315-2322. doi: 10.2147/IJN.S211076. eCollection 2020.
In order to prepare functional Au nanoparticles with low toxicity and high antitumor properties, we have used fruit waste (banana peel) to synthesize a new dendrite-shaped gold nanoparticle and used it for the treatment of tumors.
Dendrite-shaped gold nanoparticle (Au-dendrite) was synthesized through a facile hydrothermal process. The banana peel was used as both the reducing agent and the protective agent for reducing chloroauric acid to obtain Au-dendrite. The safety assessment of the Au-dendrite was conducted by H&E staining of the mouse's eyelid skin and CCK-8 assay. The antitumor effects were evaluated through in vitro tumor cytotoxicity experiments and in vivo treatment of animal tumors.
In this work, a new type of gold nanomaterial (Au-dendrite) was synthesized by using a common agricultural waste (banana peel) through a facile hydrothermal process without any extra chemical reducing agent or protective agent. Subsequent experiments showed that, compared with some classical Au nanomaterials, the as-synthesized gold nanocomposites have superior biocompatibility and impressive characteristics of dual inhibition toward tumor growth and migration.
We successfully synthesized a dendrite-shaped gold nanocomposite which was derived from a common agricultural waste (banana peel). A facile and environmentally friendly synthetic process was proposed accordingly without regular chemical additives. The as-prepared Au-dendrite nanocomposites not only had better biocompatibility than some classical gold nanoparticles but also exhibited unique advantages in tumor inhibition.
为了制备低毒性和高抗肿瘤特性的功能性金纳米粒子，我们使用水果废料（香蕉皮）合成了一种新型树枝状金纳米粒子，并将其用于肿瘤治疗。
通过简单的水热法合成树枝状金纳米粒子（Au-树枝状）。香蕉皮既用作还原剂，也用作保护剂，将氯金酸还原为 Au-树枝状。通过对小鼠眼睑皮肤进行 H&E 染色和 CCK-8 测定来评估 Au-树枝状的安全性。通过体外肿瘤细胞毒性实验和动物肿瘤的体内治疗来评估抗肿瘤效果。
在这项工作中，通过简单的水热法，使用一种常见的农业废料（香蕉皮）合成了一种新型金纳米材料（Au-树枝状），无需任何额外的化学还原剂或保护剂。随后的实验表明，与一些经典的 Au 纳米材料相比，所合成的金纳米复合材料具有更好的生物相容性和双重抑制肿瘤生长和迁移的显著特性。
我们成功地合成了一种树枝状金纳米复合材料，它来源于一种常见的农业废料（香蕉皮）。因此提出了一种简单且环保的合成工艺，无需常规的化学添加剂。所制备的 Au-树枝状纳米复合材料不仅比一些经典的金纳米粒子具有更好的生物相容性，而且在肿瘤抑制方面表现出独特的优势。
