CD4 T细胞中的非编码RNA：系统性红斑狼疮发病机制的新见解
Non-Coding RNAs in CD4 T Cells: New Insights Into the Pathogenesis of Systemic Lupus Erythematosus.
作者信息
Gao Xiaofei, Liu Limin, Min Xiaoli, Jia Sujie, Zhao Ming
机构信息
Hunan Key Laboratory of Medical Epigenomics, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China.
出版信息
Front Immunol. 2020 Apr 3;11:568. doi: 10.3389/fimmu.2020.00568. eCollection 2020.
Non-coding RNAs (ncRNAs) are indispensable for CD4 T cell differentiation and functions. By directly or indirectly regulating immune gene expression, ncRNAs give flexible instructions to guide the biological processes of CD4 T cells and play a vital role in maintaining immune homeostasis. However, the dysfunction of ncRNAs alters the gene expression profiles, disturbs the normal biological processes of CD4 T cells, and leads to the functional changes of CD4 T cells, which is an underlying cause of systemic lupus erythematosus (SLE). In this review, we focus on the recent advances in the roles of ncRNAs in CD4 T cell functions and differentiation, as well as their potential applications in the diagnosis and treatment of SLE.
非编码RNA（ncRNAs）对于CD4 T细胞的分化和功能不可或缺。通过直接或间接调节免疫基因表达，ncRNAs提供灵活的指令来指导CD4 T细胞的生物学过程，并在维持免疫稳态中发挥至关重要的作用。然而，ncRNAs的功能障碍会改变基因表达谱，扰乱CD4 T细胞的正常生物学过程，并导致CD4 T细胞的功能变化，这是系统性红斑狼疮（SLE）的一个潜在病因。在本综述中，我们重点关注ncRNAs在CD4 T细胞功能和分化中的作用的最新进展，以及它们在SLE诊断和治疗中的潜在应用。
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