Ahmed Sherine Hosny, El-Kelish Amira Ahmed, Hafeez Neveen Abdel, El-Bakry Shewikare Taweek
All authors are with the Faculty of Medicine, Benha University in Benha, Egypt.
J Clin Aesthet Dermatol. 2020 Feb;13(2):13-16. Epub 2020 Feb 1.
Acne is one of the most common skin diseases and is frequently associated with depression, social isolation, and suicidal ideation. Some studies have investigated the link of either acne or depression and serum levels of vitamin B12 and folic acid (FA), but none appear to have examined the effect of these vitamins on acne patients with or without depression. This case-control study sought to assess whether serum levels of vitamin B12 and FA could be considered possible predictors for depression and acne severity in patients with moderate and severe acne. Forty patients with acne and 40 age- and sex-matched healthy volunteers were enrolled. Acne severity and depression were assessed according to the Global Acne Grading System (GAGS) and the Arabic version of the Beck Depression Inventory II (BDI-II), respectively. Five milliliters of blood was obtained by clean venipuncture to determine B12 and FA levels by way of double-antibody sandwich enzyme-linked immunosorbent assay. According to GAGS score, moderate acne was the most prominent form of the condition (55%), followed by severe (25%) and very severe (20%). Seventy percent of patients with acne had depression according to BDI-II score versus zero percent in the control group (<0.001). Patients with moderate and severe acne in this study had significantly lower serum levels of vitamin B12 and FA when compared to controls (=0.012 and <0.001) and their levels showed a significant negative correlation with acne severity according to GAGS score. Screening for vitamin B12 and FA deficiency can be particularly relevant in patients with acne to assess depression risk. Folate supplementation should be considered for patients with acne and comorbid depression.
痤疮是最常见的皮肤病之一，常与抑郁、社交孤立和自杀观念相关。一些研究调查了痤疮或抑郁与血清维生素B12和叶酸（FA）水平之间的联系，但似乎没有一项研究考察过这些维生素对伴有或不伴有抑郁的痤疮患者的影响。 这项病例对照研究旨在评估血清维生素B12和FA水平是否可被视为中重度痤疮患者抑郁和痤疮严重程度的可能预测指标。 招募了40名痤疮患者和40名年龄及性别匹配的健康志愿者。分别根据全球痤疮分级系统（GAGS）和贝克抑郁量表第二版（BDI-II）阿拉伯语版评估痤疮严重程度和抑郁情况。通过清洁静脉穿刺采集5毫升血液，采用双抗体夹心酶联免疫吸附测定法测定B12和FA水平。 根据GAGS评分，中度痤疮是最主要的类型（55%），其次是重度（25%）和极重度（20%）。根据BDI-II评分，70%的痤疮患者有抑郁，而对照组为零（<0.001）。 与对照组相比，本研究中中重度痤疮患者的血清维生素B12和FA水平显著降低（=0.012和<0.001），且根据GAGS评分，其水平与痤疮严重程度呈显著负相关。 对痤疮患者进行维生素B12和FA缺乏筛查对于评估抑郁风险可能尤为重要。对于伴有抑郁的痤疮患者，应考虑补充叶酸。
