Awad Sara M, Morsy Hanan, Sayed Ayat A, Mohamed Nahed A, Ezzat Ghada M, Noaman Mostafa M
Faculty of Medicine, Department of Dermatology and Venereology, Assiut University, Assiut, Egypt.
Faculty of Medicine, Department of Medical Biochemistry, Assiut University, Assiut, Egypt.
J Cosmet Dermatol. 2018 Apr;17(2):203-208. doi: 10.1111/jocd.12366. Epub 2017 Jun 20.
Acne vulgaris is a common cosmetic problem that is frequently associated with psychosocial disturbances as well as increased oxidative stress. However, oxidative stress and psychological aspects have been studied separately in acne.
To evaluate the relationships between oxidative stress, anxiety, depression, and quality of life in acne patients.
Sixty patients with facial acne and 40 age- and sex-matched healthy individuals were included in the study. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS), and quality of life (QoL) was measured by the Cardiff Acne Disability Index. Disease severity was assessed using the Combined Acne Severity Classification. The serum levels of zinc and malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured in patients and healthy subjects.
The mean HADS scores for anxiety and depression were higher in patients than controls (P<.001 for both). Acne patients showed higher serum MDA and lower TAC and serum zinc levels compared with control subjects (P=.019, P<.001, and P=.028, respectively). Anxiety and depression scores did not correlate with oxidative stress parameters. Patients with moderate/severe acne had worse anxiety scores than mild acne (P=.048), and higher anxiety scores were associated with poorer quality of life (r=.436, P=.001).
Our results indicate that the high levels of anxiety and depression in patients with facial acne were not related to oxidative stress. Anxiety was more common than depression and was directly related to QoL impairment.
寻常痤疮是一种常见的美容问题，常与心理社会障碍以及氧化应激增加有关。然而，在痤疮研究中，氧化应激和心理方面一直是分开进行研究的。
评估痤疮患者氧化应激、焦虑、抑郁与生活质量之间的关系。
本研究纳入了60例面部痤疮患者和40例年龄及性别匹配的健康个体。使用医院焦虑抑郁量表（HADS）评估焦虑和抑郁情况，采用卡迪夫痤疮残疾指数测量生活质量（QoL）。使用联合痤疮严重程度分类评估疾病严重程度。检测患者和健康受试者血清锌、丙二醛（MDA）水平及总抗氧化能力（TAC）。
患者的焦虑和抑郁HADS平均得分高于对照组（两者P均<.001）。与对照组相比，痤疮患者血清MDA水平较高，TAC和血清锌水平较低（分别为P =.019、P<.001和P =.028）。焦虑和抑郁评分与氧化应激参数无相关性。中度/重度痤疮患者的焦虑评分高于轻度痤疮患者（P =.048），较高的焦虑评分与较差的生活质量相关（r =.436，P =.001）。
我们的结果表明，面部痤疮患者的高焦虑和抑郁水平与氧化应激无关。焦虑比抑郁更常见，且与生活质量受损直接相关。
