Kemeriz Funda, Tuncer Sibel Çiğdem, Acar Emine Müge, Tuğrul Burcu
Department of Dermatology, Aksaray University Faculty of Medicine, Aksaray, Turkey.
Department of Biochemistry, Aksaray University Faculty of Medicine, Aksaray, Turkey.
Dermatol Ther. 2020 May;33(3):e13393. doi: 10.1111/dth.13393. Epub 2020 May 6.
Acne vulgaris is a multifactorial skin disorder. Many etiological factors are speculated to contribute to the pathogenesis of acne, one of these is vitamin D deficiency. Previous studies reported contradictory results about serum 25 hydroxy vitamin D (25-OH vitamin D) levels, its association with acne, some claimed that acne lesion might improve with vitamin D supplementation. We aimed to assess serum 25-OH vitamin D levels in acne patients, identify their relation with disease severity in a larger study group. The study included 134 acne patients, 129 controls. Acne disease severity was identified with Global Acne Grading Scale (GAGS) scores. Serum 25-OH vitamin D levels were measured in all groups. Serum 25-OH vitamin D levels were significantly lower in acne patients than in controls (P < .001). The prevalence of vitamin D deficiency was significantly higher in acne group than in control group (77.6% vs 63.9%; P = .041). There was a negative-strong statistically significant correlation detected between serum 25-OH vitamin D levels and GAGS scores in patient group (P < .001; r = -.910). According to these results, we claim that evaluating serum 25-OH vitamin D levels in acne patients, vitamin D supplementation as a treatment option may be a consideration for further studies.
寻常痤疮是一种多因素皮肤疾病。许多病因被推测与痤疮的发病机制有关，其中之一是维生素D缺乏。先前的研究报告了关于血清25-羟基维生素D（25-OH维生素D）水平及其与痤疮关联的相互矛盾的结果，一些人声称补充维生素D可能会改善痤疮皮损。我们旨在评估痤疮患者的血清25-OH维生素D水平，在一个更大的研究组中确定其与疾病严重程度的关系。该研究纳入了134例痤疮患者和129例对照。用全球痤疮分级量表（GAGS）评分来确定痤疮疾病的严重程度。测量了所有组的血清25-OH维生素D水平。痤疮患者的血清25-OH维生素D水平显著低于对照组（P < .001）。痤疮组维生素D缺乏的患病率显著高于对照组（77.6%对63.9%；P = .041）。在患者组中，血清25-OH维生素D水平与GAGS评分之间检测到具有统计学意义的强负相关（P < .001；r = -.910）。根据这些结果，我们认为评估痤疮患者的血清25-OH维生素D水平，补充维生素D作为一种治疗选择可能值得进一步研究。
