Iqbal Tayyaba, Asim Sadaf Ahmed, Bhatti Sadia, Sajid Madiha, Mirza Reema, Huma Zille
Department of Dermatology, Dow University of Health Sciences, Karachi, Pakistan.
Department of General Medicine, Dow University of Health Sciences, Karachi, Pakistan.
J Coll Physicians Surg Pak. 2023 May;33(5):527-530. doi: 10.29271/jcpsp.2023.05.527.
To determine the association of vitamin D deficiency in moderate to severe acne.
A comparative study. Place and Duration of the Study: Dermatology OPD at Dow University of Health Sciences, Karachi, Pakistan, from December 2021 to May 2022.
Fifty patients with moderate acne, 50 patients with severe acne, and 50 healthy controls were inducted. Information regarding age, gender, and medical and medication history were taken. The severity of acne was rated according to the GAGS (global acne grading system) score. Levels of 25(OH) D were classified as sufficient (>20 ng/mL), insufficient (12-20 ng/mL), or deficient (<12 ng/mL). Significance was taken at p-value <0.05.
The median concentration of vitamin D levels was 7.09 ng/ml in severe acne vulgaris, 13.7 ng/ml in moderate acne vulgaris and 21.6ng/ml in the control group. Serum vitamin D levels were significantly lower (p<0.001) in individuals with acne vulgaris as compared to the healthy controls. However, the decrease in level of vitamin D did not correspond with the severity of acne vulgaris.
Vitamin D deficiency is additionally pronounced in acne vulgaris individuals, but vitamin D levels are not proportional to the severity of acne vulgaris.
Acne vulgaris, Vitamin D deficiency, Pilosebaceous unit, GAGS score.
确定中度至重度痤疮患者维生素D缺乏之间的关联。
一项对比研究。研究地点和时间：2021年12月至2022年5月在巴基斯坦卡拉奇健康科学道氏大学皮肤科门诊。
纳入50例中度痤疮患者、50例重度痤疮患者和50例健康对照者。收集有关年龄、性别、病史和用药史的信息。根据全球痤疮分级系统（GAGS）评分对痤疮严重程度进行分级。25（OH）D水平分为充足（>20 ng/mL）、不足（12 - 20 ng/mL）或缺乏（<12 ng/mL）。以p值<0.05为有统计学意义。
重度寻常痤疮患者维生素D水平的中位数为7.09 ng/ml，中度寻常痤疮患者为13.7 ng/ml，对照组为21.6 ng/ml。与健康对照者相比，寻常痤疮患者的血清维生素D水平显著降低（p<0.001）。然而，维生素D水平的降低与寻常痤疮的严重程度并不对应。
寻常痤疮患者中维生素D缺乏更为明显，但维生素D水平与寻常痤疮的严重程度不成比例。
寻常痤疮；维生素D缺乏；毛囊皮脂腺单位；GAGS评分
