Singh Neelu, Das Monoj Kumar, Ramteke Anand, R Paulraj
School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.
Cancer Genetics and Chemoprevention Research Group, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, 784028 Assam, India.
Toxicol Rep. 2020 Mar 27;7:492-500. doi: 10.1016/j.toxrep.2020.03.009. eCollection 2020.
Zinc oxide nanoparticles (ZNP) are being used in various fields viz cosmetics industry as UV protectants, in the food packaging industry due to their anti-bacterial properties, in agriculture as micronutrients, etc. Increased applications of ZNPs in our day to day life, leading to the contamination of the surrounding environment posing a direct or indirect health risk. Various reports suggest that fruits and vegetables are a rich source of phytochemicals having antioxidant properties which help in neutralizing ROS generated on metal toxicity of the body. The present study focuses to study the ameliorative effect of apple () extract (E) on ZNP induced toxicity. Therefore, animals were grouped, six in each, exposed to various doses of ZNP (50 and 250 mg/kg), ZNP (50 and 250 mg/kg)+E. The studied parameters was: food intake, water intake, antioxidants assay, zinc accumulation, and histological alterations and was compared to control. Investigation revealed that ZNP induces toxicity as revealed by the alteration in the studied parameter, whereas those exposed to ZNP along with Pyrus malus fruit extract try to reduce the toxicity induced by nanoparticles but at low doses only. This ameliorative effect of fruit extract might be due to the presence of antioxidants scavenging the free radicals generated by ZNPs suggesting that antioxidant-rich fruit may have a protective role and have the potential to reduce the nanoparticles mediated oxidative stress.
氧化锌纳米颗粒（ZNP）正被应用于各个领域，如在化妆品行业用作紫外线防护剂，在食品包装行业因其抗菌特性而被使用，在农业中作为微量营养素等。ZNP在我们日常生活中的应用日益增加，导致周围环境污染，对健康构成直接或间接风险。各种报告表明，水果和蔬菜富含具有抗氧化特性的植物化学物质，有助于中和体内金属毒性产生的活性氧。本研究旨在研究苹果（）提取物（E）对ZNP诱导的毒性的改善作用。因此，将动物分组，每组6只，分别暴露于不同剂量的ZNP（50和250毫克/千克）、ZNP（50和250毫克/千克）+E。所研究的参数包括：食物摄入量、饮水量、抗氧化剂测定、锌积累以及组织学改变，并与对照组进行比较。调查显示，所研究参数的改变表明ZNP会诱导毒性，而那些同时暴露于ZNP和苹果果实提取物的动物试图降低纳米颗粒诱导的毒性，但仅在低剂量时有效。水果提取物的这种改善作用可能是由于其中存在抗氧化剂，能够清除ZNP产生的自由基，这表明富含抗氧化剂的水果可能具有保护作用，并有潜力减少纳米颗粒介导的氧化应激。
