与旧世界皮肤利什曼病相关的营养摄入与慢性病：维生素A的作用。
Nutritional Intake and Chronicity Associated with the Old World Cutaneous Leishmaniasis: Role of Vitamin A.
作者信息
Mashayekhi Goyonlo Vahid, Norouzy Abdolreza, Nemati Mohsen, Layegh Pouran, Akhlaghi Saeed, Taheri Ahmad Reza, Kiafar Bita
机构信息
Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Biochemistry of Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Iran J Public Health. 2020 Jan;49(1):167-172.
BACKGROUND
Old world cutaneous leishmaniasis (CL) is known as a self-healing cutaneous parasitic infection. Host immunity has a fundamental role in the course of this infection. This study was designed to investigate the relationship between nutritional status and vitamin A intake with the clinical course of CL.
METHODS
Overall, 250 patients with CL attending a dermatology clinic in Imam Reza Hospital Mashhad, Iran, were enrolled from Apr 2011 to Aug 2012. For data gathering, a semi-quantitative 302-item food frequency questionnaire was utilized. They received routine treatment protocols for leishmaniasis and 1 year of follow-up.
RESULTS
As for the 149 patients who completed the study, a deficiency of macro and micronutrients, particularly vitamin A, was significantly related to a chronic clinical disease course.
CONCLUSION
Imbalanced or insufficient nutritional intake including vitamin A deficiency, may influence the clinical course of CL.
背景
旧世界皮肤利什曼病（CL）是一种可自愈的皮肤寄生虫感染。宿主免疫在这种感染过程中起着至关重要的作用。本研究旨在调查营养状况和维生素A摄入量与CL临床病程之间的关系。
方法
2011年4月至2012年8月，共招募了250例在伊朗马什哈德伊玛目礼萨医院皮肤科就诊的CL患者。为收集数据，采用了一份包含302个项目的半定量食物频率问卷。他们接受了利什曼病的常规治疗方案并随访1年。
结果
对于完成研究的149例患者，大量营养素和微量营养素缺乏，尤其是维生素A缺乏，与慢性临床病程显著相关。
结论
包括维生素A缺乏在内的营养摄入不均衡或不足，可能会影响CL的临床病程。
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