• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The value of calcium dobesilate in the treatment of diabetic retinopathy. A controlled clinical trial.

作者信息

Larsen H W, Sander E, Hoppe R

出版信息

Diabetologia. 1977 Apr;13(2):105-9. doi: 10.1007/BF00745136.

DOI:10.1007/BF00745136
PMID:323093
Abstract

The effect of calcium dobesilate on capillary resistance and background retinopathy was compared with placebo in a double-blind cross-over trial on 18 diabetics. Each treatment lasted 8 months. The trial produced no evidence in favour of a significant beneficial effect of calcium dobesilate on the capillary resistance in diabetics or on the course of the diabetic retinopathy.

摘要

相似文献

1
The value of calcium dobesilate in the treatment of diabetic retinopathy. A controlled clinical trial.
Diabetologia. 1977 Apr;13(2):105-9. doi: 10.1007/BF00745136.
2
Calcium dobesilate versus placebo in the treatment of diabetic retinopathy: a double-blind cross-over study.
Curr Ther Res Clin Exp. 1976 Sep;20(3):283-8.
3
The effect of calcium dobesilate on nonproliferative diabetic retinopathy: a controlled study.羟苯磺酸钙对非增殖性糖尿病视网膜病变的影响：一项对照研究。
Ophthalmology. 1978 Jun;85(6):594-606. doi: 10.1016/s0161-6420(78)35643-8.
4
Assessment of calcium dobesilate in diabetic retinopathy. A double-blind clinical investigation.
Ophthalmologica. 1977;174(1):47-51. doi: 10.1159/000308575.
5
[5 years experimentation with calcium dobesilate in the treatment of retinopathies].
Ophthalmologica. 1975;170(2-3):232-8. doi: 10.1159/000307210.
6
A controlled clinical trial of calcium dobesylate in the treatment of diabetic retinopathy.
Diabete Metab. 1977 Mar;3(1):27-30.
7
Treatment of blood hyperviscosity with calcium dobesilate in patients with diabetic retinopathy.羟苯磺酸钙治疗糖尿病视网膜病变患者的血液高黏滞状态
Ophthalmic Res. 1985;17(3):131-8. doi: 10.1159/000265364.
8
Influence of calcium dobesilate (Doxium) on blood viscosity and coagulation parameters in diabetic retinopathy.
Vasa. 1987;16(2):190-2.
9
Calcium dobesilate in diabetic retinopathy. A retrospective controlled study.羟苯磺酸钙治疗糖尿病视网膜病变。一项回顾性对照研究。
Ophthalmologica. 1985;190(2):102-11. doi: 10.1159/000309502.
10
[Treatment of the diabetic retinopathy with doxium-clofibrate (author's transl)].
Klin Monbl Augenheilkd. 1976 Mar;168(3):377-86.

引用本文的文献

1
A single-dose, randomized crossover study in healthy Chinese subjects to evaluate pharmacokinetics and bioequivalence of two capsules of calcium dobesilate 0.5 g under fasting and fed conditions.一项在中国健康受试者中进行的单次、随机交叉研究，旨在评估空腹和进食条件下两种 0.5 克羟苯磺酸钙胶囊的药代动力学和生物等效性。
PLoS One. 2023 Apr 21;18(4):e0284576. doi: 10.1371/journal.pone.0284576. eCollection 2023.
2
Efficacy of calcium dobesilate in treating Chinese patients with mild-to-moderate non-proliferative diabetic retinopathy (CALM-DR): protocol for a single-blind, multicentre, 24-armed cluster-randomised, controlled trial.羟苯磺酸钙治疗中国轻中度非增殖期糖尿病视网膜病变患者的疗效（CALM-DR）：一项单盲、多中心、24 臂分组随机对照临床试验方案。
BMJ Open. 2021 May 28;11(5):e045256. doi: 10.1136/bmjopen-2020-045256.
3

本文引用的文献

1
Quantitative measurements of skin capillary resistance in hypophysectomized long-term diabetics.垂体切除的长期糖尿病患者皮肤毛细血管阻力的定量测量
Diabetes. 1971 May;20(5):297-301. doi: 10.2337/diab.20.5.297.
2
The action of calcium dobesilate on capillary permeability in diabetics.羟苯磺酸钙对糖尿病患者毛细血管通透性的作用。
Ophthalmologica. 1971;162(1):33-40. doi: 10.1159/000306232.
3
[Treatment of diabetic retinopathy and recurrent hemorrhages into the vitreous with calcium dobesilate].用羟苯磺酸钙治疗糖尿病性视网膜病变及玻璃体反复出血
Update on the Effects of Antioxidants on Diabetic Retinopathy: In Vitro Experiments, Animal Studies and Clinical Trials.抗氧化剂对糖尿病视网膜病变影响的最新进展：体外实验、动物研究及临床试验
Antioxidants (Basel). 2020 Jun 26;9(6):561. doi: 10.3390/antiox9060561.
4
Calcium dobesilate reduces endothelin-1 and high-sensitivity C-reactive protein serum levels in patients with diabetic retinopathy.羟苯磺酸钙可降低糖尿病视网膜病变患者的内皮素-1和高敏C反应蛋白血清水平。
Mol Vis. 2013;19:62-8. Epub 2013 Jan 10.
5
Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes.羟苯磺酸钙可抑制糖尿病引起的视网膜内皮细胞紧密连接蛋白改变和白细胞黏附。
Diabetes. 2010 Oct;59(10):2637-45. doi: 10.2337/db09-1421. Epub 2010 Jul 13.
6
Effectiveness and cost-benefit analysis of intensive treatment and teaching programmes for type 1 (insulin-dependent) diabetes mellitus in Moscow--blood glucose versus urine glucose self-monitoring.
Diabetologia. 1994 Feb;37(2):170-6. doi: 10.1007/s001250050089.
Ophthalmologica. 1970;161(4):389-93. doi: 10.1159/000306158.
4
Caclium dobesilate in diabetic retinopathy.
Ophthalmologica. 1969;159(1):126-35. doi: 10.1159/000305894.
5
[Decrease of vascular fragility in diabetic retinopathy through calciumdobesilate (author's transl)].通过羟苯磺酸钙降低糖尿病视网膜病变中的血管脆性（作者译）
Klin Monbl Augenheilkd. 1974 Feb;164(2):246-51.
6
Capillary fragility and doxium. A controlled clinical trial.毛细血管脆性与多柔比星。一项对照临床试验。
Diabetologia. 1973 Dec;9(6):483-5. doi: 10.1007/BF00461693.
7
Microvascular protection with calcium dobesilate (Doxium) in diabetic retinopathy.羟苯磺酸钙（多贝斯）对糖尿病视网膜病变的微血管保护作用
Ophthalmologica. 1974;168(5):400-16. doi: 10.1159/000307064.
8
[Exudative diabetic retinopathy. A fluorescence angiography study].[渗出性糖尿病视网膜病变。一项荧光血管造影研究]
Ophthalmologica. 1975;170(6):518-33. doi: 10.1159/000307260.