Stamper R L, Smith M E, Aronson S B, Cavender J C, Cleasby G W, Fung W E, Becker B
Ophthalmology. 1978 Jun;85(6):594-606. doi: 10.1016/s0161-6420(78)35643-8.
Two independent, double-masked, controlled studies were made to evaluate the efficacy of calcium dobesilate for the treatment of nonproliferative diabetic retinopathy. Forty-two patients underwent a six-month crossover evaluation while receiving calcium dobesilate (750 mg per day) and placebo in random order. Thirty-six patients received calcium dobesilate (1,000 mg per day) or placebo for one year. Evaluation by clinical examination, fluorescein angiography, angiography, and fundus photography failed to demonstrate any beneficial effect of calcium dobesilate.
进行了两项独立、双盲、对照研究，以评估羟苯磺酸钙治疗非增殖性糖尿病视网膜病变的疗效。42例患者接受了为期6个月的交叉评估，随机顺序接受羟苯磺酸钙（每日750毫克）和安慰剂治疗。36例患者接受羟苯磺酸钙（每日1000毫克）或安慰剂治疗1年。通过临床检查、荧光素血管造影、血管造影和眼底摄影进行评估，未发现羟苯磺酸钙有任何有益效果。
