Benarroch I S, Brodsky M, Rubinstein A, Viggiano C, Salama E A
Ophthalmic Res. 1985;17(3):131-8. doi: 10.1159/000265364.
This double-blind randomized trial was carried out on 37 patients with diabetic retinopathy and blood hyperviscosity. 19 patients received calcium dobesilate in capsules of 500 mg 3 times daily for 3 months and 18 patients took 3 placebo capsules daily during the same period. Calcium dobesilate was found to reduce whole-blood viscosity in a statistically significant manner which was accompanied by a diminution of the albumin/globulin ratio and a significant reduction of fibrinogen and cholesterol levels. A statistically significant diminution of capillary fragility was also observed in the calcium dobesilate-treated group. These results indicate that calcium dobesilate, by restoring the integrity of the microvessels, and by lowering blood viscosity, could act favorably on the evolution of diabetic retinopathy.
这项双盲随机试验对37例患有糖尿病视网膜病变和血液高黏滞度的患者进行。19例患者接受多贝斯钙片，每次500毫克，每日3次，持续3个月；18例患者在同一时期每日服用3粒安慰剂胶囊。结果发现，多贝斯钙能显著降低全血黏度，同时白蛋白/球蛋白比值降低，纤维蛋白原和胆固醇水平显著降低。在多贝斯钙治疗组中还观察到毛细血管脆性有统计学意义的降低。这些结果表明，多贝斯钙通过恢复微血管的完整性和降低血液黏度，可能对糖尿病视网膜病变的发展产生有利作用。
