The role of the gene family in ovarian cancer.

BACKGROUND

Ovarian cancer is a frequently-occurring reproductive system malignancy in females, which leads to an annual of over 100 thousand deaths worldwide.

METHODS

The electronic databases, including GEPIA, ONCOMINE, Metascape, and Kaplan-Meier Plotter, were used to examine both survival and transcriptional data regarding the cell division cycle associated () gene family among ovarian cancer patients.

RESULTS

All genes expression levels were up-regulated in ovarian cancer tissues relative to those in non-carcinoma ovarian counterparts. Besides, expression levels were related to the late tumor stage. In addition, the Kaplan-Meier Plotter database was employed to carry out survival analysis, which suggested that ovarian cancer patients with increased expression levels had poor overall survival (OS) (P<0.05). Moreover, ovarian cancer patients that had up-regulated mRNA expression levels of had markedly reduced progression-free survival (PFS) (P<0.05); and up-regulated expression showed remarkable association with reduced post-progression survival (PPS) (P<0.05). Additionally, the following processes were affected by genes alterations, including R-HAS-2500257: resolution of sister chromatid cohesion; GO:0051301: cell division; CORUM: 1118: Chromosomal passenger complex (CPC, including , , and ); CORUM: 127: NDC80 kinetochore complex; M129: PID PLK1 pathway; and GO: 0007080: mitotic metaphase plate congression, all of which were subjected to marked regulation since the alterations affected genes.

CONCLUSIONS

Up-regulated gene expression in ovarian cancer tissues probably played a crucial part in the occurrence of ovarian cancer. The up-regulated expression levels were used as the potential prognostic markers to improve the poor ovarian cancer survival and prognostic accuracy. Moreover, genes probably exerted their functions in tumorigenesis through the PLK1 pathway.