Shah Jamil, Lingiah Vivek, Pyrsopoulos Nikolaos, Galan Mark
Division of Gastroenterology and Hepatology, Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ.
Department of Pathology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ.
ACG Case Rep J. 2020 Feb 24;7(2):e00325. doi: 10.14309/crj.0000000000000325. eCollection 2020 Feb.
Epstein-Barr virus (EBV) is a widely dispersed herpesvirus, transferred through close personal contact between susceptible individuals and asymptomatic shedders of the virus. The liver is often affected, and involvement is usually subclinical and self-limited. However, immunocompromised patients and, more rarely, immunocompetent individuals can develop a severe and potentially fatal acute liver injury. To differentiate EBV hepatitis from other conditions, such as autoimmune hepatitis, lymphoproliferative disorders, and drug-induced liver injury, correlation with clinical history, laboratory findings, and histopathologic features is crucial. We report a unique case of a man who developed acute liver injury from a severe EBV infection.
爱泼斯坦-巴尔病毒（EBV）是一种广泛传播的疱疹病毒，通过易感个体与该病毒无症状排毒者之间的密切个人接触传播。肝脏常受影响，且受累通常为亚临床的且具有自限性。然而，免疫功能低下的患者，以及更罕见的免疫功能正常的个体，可能会发生严重且可能致命的急性肝损伤。为了将EBV肝炎与其他疾病，如自身免疫性肝炎、淋巴增殖性疾病和药物性肝损伤相鉴别，与临床病史、实验室检查结果和组织病理学特征进行关联至关重要。我们报告了一例因严重EBV感染导致急性肝损伤的独特病例。
