爱泼斯坦-巴尔病毒引起的伴有高铁蛋白血症的急性肝炎：一种罕见的表现。
Epstein-Barr virus induced acute hepatitis with hyperferritinemia: A rare presentation.
作者信息
Theodory Bassam, Dopp Meena, Swisher Austin R, Flores Roberto M, Robb Paul M
机构信息
University of California, Riverside, School of Medicine, Riverside, CA, USA.
Department of Internal Medicine, Kaiser Permanente, Inland Empire, Fontana, CA, USA.
出版信息
IDCases. 2023 Aug 9;33:e01872. doi: 10.1016/j.idcr.2023.e01872. eCollection 2023.
Elevated aminotransaminases and hyperbilirubinemia are common in primary Epstein-Barr Virus (EBV) infection in the adult and pediatric population and the disease course is usually subclinical and self-limited. However, EBV-induced hepatitis is an uncommon diagnosis, accounting for less than 1% of acute hepatitis causes. Acute EBV-hepatitis usually affects immunocompromised and older populations, with nearly half of patients being aged greater than 60 years. Significantly elevated ferritin levels correlate with severe infection and have been associated with EBV complications such as infectious mononucleosis, autoimmune hemolytic anemia, and hemophagocytic lymphohistiocytosis. We present a case of isolated acute cholestatic EBV-hepatitis and hyperferritinemia in an adult immunocompetent patient.
转氨酶升高和高胆红素血症在成人和儿童原发性爱泼斯坦-巴尔病毒（EBV）感染中很常见，且病程通常为亚临床和自限性。然而，EBV 诱导的肝炎是一种罕见的诊断，占急性肝炎病因的不到 1%。急性 EBV 肝炎通常影响免疫功能低下和老年人群，近一半患者年龄大于 60 岁。铁蛋白水平显著升高与严重感染相关，并与 EBV 并发症如传染性单核细胞增多症、自身免疫性溶血性贫血和噬血细胞性淋巴组织细胞增生症有关。我们报告一例成年免疫功能正常患者的孤立性急性胆汁淤积性 EBV 肝炎和高铁蛋白血症病例。
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