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Association between direct-acting oral anticoagulants vs. warfarin with the risk of osteoporosis in patients with non-valvular atrial fibrillation.非瓣膜性心房颤动患者中直接口服抗凝剂与华法林相比与骨质疏松症风险的关联。
Int J Cardiol Heart Vasc. 2020 Feb 16;27:100484. doi: 10.1016/j.ijcha.2020.100484. eCollection 2020 Apr.
2
Use of oral anticoagulants in complex clinical situations with atrial fibrillation.在伴有房颤的复杂临床情况下使用口服抗凝药物。
Med Clin (Barc). 2018 Jun;150 Suppl 1:8-24. doi: 10.1016/S0025-7753(18)30666-3.
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Oral anticoagulants usage in Japanese patients aged 18-74 years with non-valvular atrial fibrillation: a retrospective analysis based on insurance claims data.基于保险理赔数据的 18-74 岁非瓣膜性心房颤动日本患者的口服抗凝药物使用情况：一项回顾性分析。
Fam Pract. 2019 Nov 18;36(6):685-692. doi: 10.1093/fampra/cmz016.
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Effectiveness and Safety of Anticoagulants in Adults with Non-valvular Atrial Fibrillation and Concomitant Coronary/Peripheral Artery Disease.非瓣膜性心房颤动合并冠状动脉/外周动脉疾病成人患者抗凝治疗的有效性和安全性。
Am J Med. 2018 Sep;131(9):1075-1085.e4. doi: 10.1016/j.amjmed.2018.05.007. Epub 2018 May 26.
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Comparison of major bleeding risk in patients with non-valvular atrial fibrillation receiving direct oral anticoagulants in the real-world setting: a network meta-analysis.真实世界中接受直接口服抗凝剂治疗的非瓣膜性心房颤动患者主要出血风险的比较：一项网状Meta分析。
Curr Med Res Opin. 2018 Mar;34(3):487-498. doi: 10.1080/03007995.2017.1411793. Epub 2017 Dec 8.
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Risk of major bleeding in patients with non-valvular atrial fibrillation treated with oral anticoagulants: a systematic review of real-world observational studies.口服抗凝剂治疗非瓣膜性心房颤动患者的大出血风险：真实世界观察性研究的系统评价
Curr Med Res Opin. 2017 Sep;33(9):1583-1594. doi: 10.1080/03007995.2017.1347090. Epub 2017 Jul 6.
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Cost-Effectiveness Analysis of Direct-Acting Oral Anticoagulants for Stroke Prevention in Thai Patients with Non-Valvular Atrial Fibrillation and a High Risk of Bleeding.直接口服抗凝剂用于预防伴有高出血风险的非瓣膜性心房颤动泰国患者中风的成本效益分析。
Pharmacoeconomics. 2019 Feb;37(2):279-289. doi: 10.1007/s40273-018-0741-3.
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Selection of Oral Anticoagulants in Ischemic Stroke Patients with Nonvalvular Atrial Fibrillation.非瓣膜性心房颤动缺血性卒中患者口服抗凝剂的选择
J Stroke Cerebrovasc Dis. 2018 Oct;27(10):2627-2631. doi: 10.1016/j.jstrokecerebrovasdis.2018.05.036. Epub 2018 Jun 30.
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Effect and risk of novel oral anticoagulants versus warfarin in patients with non-valvular atrial fibrillation.新型口服抗凝药与华法林治疗非瓣膜性心房颤动患者的疗效及风险
J Cardiol. 2017 Jul;70(1):99. doi: 10.1016/j.jjcc.2016.12.017. Epub 2017 Feb 13.
10
Anticoagulation for stroke prevention in elderly patients with non-valvular atrial fibrillation: what are the obstacles?老年非瓣膜性心房颤动患者预防卒中的抗凝治疗：障碍有哪些？
Hong Kong Med J. 2016 Dec;22(6):608-15. doi: 10.12809/hkmj154803.

引用本文的文献

1
Recent highlights on thrombosis and hemostasis from the International Journal of Cardiology: Heart & Vasculature.《国际心脏病学杂志：心脏与血管》关于血栓形成与止血的近期亮点。
Int J Cardiol Heart Vasc. 2022 Dec;43:101145. doi: 10.1016/j.ijcha.2022.101145. Epub 2022 Nov 5.
2
Breaking bad: Higher risk of osteoporosis with vitamin K antagonists compared to direct oral anticoagulants in patients with atrial fibrillation.不良影响：与直接口服抗凝剂相比，房颤患者使用维生素K拮抗剂时患骨质疏松症的风险更高。
Int J Cardiol Heart Vasc. 2020 Apr 10;27:100487. doi: 10.1016/j.ijcha.2020.100487. eCollection 2020 Apr.

本文引用的文献

1
Association of Anticoagulant Therapy With Risk of Fracture Among Patients With Atrial Fibrillation.抗凝治疗与房颤患者骨折风险的相关性。
JAMA Intern Med. 2020 Feb 1;180(2):245-253. doi: 10.1001/jamainternmed.2019.5679.
2
Osteoporotic Fractures in Patients With Atrial Fibrillation Treated With Conventional Versus Direct Anticoagulants.骨质疏松性骨折在接受常规抗凝剂与直接抗凝剂治疗的心房颤动患者中的比较。
J Am Coll Cardiol. 2019 Oct 29;74(17):2150-2158. doi: 10.1016/j.jacc.2019.08.1025.
3
A Systematic Review and Meta-analysis of the Association Between Vitamin K Antagonist Use and Fracture.维生素 K 拮抗剂使用与骨折相关性的系统评价和荟萃分析。
J Gen Intern Med. 2019 Feb;34(2):304-311. doi: 10.1007/s11606-018-4758-2. Epub 2018 Dec 3.
4
Non-vitamin K Antagonist Oral Anticoagulants vs. Warfarin at Risk of Fractures: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.非维生素K拮抗剂口服抗凝药与华法林在骨折风险方面的比较：一项随机对照试验的系统评价和荟萃分析
Front Pharmacol. 2018 Apr 10;9:348. doi: 10.3389/fphar.2018.00348. eCollection 2018.
5
Association Between Dabigatran vs Warfarin and Risk of Osteoporotic Fractures Among Patients With Nonvalvular Atrial Fibrillation.达比加群与华法林在非瓣膜性心房颤动患者中与骨质疏松性骨折风险的相关性。
JAMA. 2017 Mar 21;317(11):1151-1158. doi: 10.1001/jama.2017.1363.
6
Effects on bone metabolism markers and arterial stiffness by switching to rivaroxaban from warfarin in patients with atrial fibrillation.心房颤动患者从华法林转换为利伐沙班对骨代谢标志物和动脉僵硬度的影响。
Heart Vessels. 2017 Aug;32(8):977-982. doi: 10.1007/s00380-017-0950-2. Epub 2017 Feb 23.
7
Differential Effects of Dabigatran and Warfarin on Bone Volume and Structure in Rats with Normal Renal Function.达比加群与华法林对肾功能正常大鼠骨体积和结构的不同影响。
PLoS One. 2015 Aug 4;10(8):e0133847. doi: 10.1371/journal.pone.0133847. eCollection 2015.
8
Incident long-term warfarin use and risk of osteoporotic fractures: propensity-score matched cohort of elders with new onset atrial fibrillation.事件性长期华法林使用与骨质疏松性骨折风险：伴有新发心房颤动的老年人新发病例倾向性评分匹配队列研究。
Osteoporos Int. 2014 Jun;25(6):1677-84. doi: 10.1007/s00198-014-2662-0. Epub 2014 Mar 29.
9
Effects of risedronate alone or combined with vitamin K2 on serum undercarboxylated osteocalcin and osteocalcin levels in postmenopausal osteoporosis.利塞膦酸盐单独或联合维生素K2对绝经后骨质疏松症患者血清未羧化骨钙素和骨钙素水平的影响
J Bone Miner Metab. 2014 May;32(3):290-7. doi: 10.1007/s00774-013-0490-5. Epub 2013 Jul 12.
10
Warfarin use and risk for osteoporosis in elderly women. Study of Osteoporotic Fractures Research Group.
Ann Intern Med. 1998 May 15;128(10):829-32. doi: 10.7326/0003-4819-128-10-199805150-00006.

Association between direct-acting oral anticoagulants vs. warfarin with the risk of osteoporosis in patients with non-valvular atrial fibrillation.

作者信息

Akhtar Tauseef, Hajra Adrija, Bhyan Poonam, Ghosh Raktim K, Bandyopadhyay Dhrubajyoti, Aronow Wilbert S

机构信息

John's Hopkins University School of Medicine, Baltimore, USA.

Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.

出版信息

Int J Cardiol Heart Vasc. 2020 Feb 16;27:100484. doi: 10.1016/j.ijcha.2020.100484. eCollection 2020 Apr.

DOI:10.1016/j.ijcha.2020.100484
PMID:32309531
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7154295/
Abstract
摘要