Miller D J, Dwyer J M, Klatskin G
Gastroenterology. 1977 Jun;72(6):1199-203.
The lymphocytes infiltrating the liver were isolated and characterized as T or B cells in three groups of patients: 20 patients with hepatitis B surface antigen (HB sAg)-positive acute and chronic hepatitis, 8 patients with HBsAg-negative chronic hepatitis with prior evidence for hepatitis B virus (HBV) infection, and 5 patients with HBsAg-negative chronic hepatitis without prior evidence for HBV infection. The predominant cell infiltrating the liver was shown to be a T cell in all categories; however, the ratio of T:B cells was significantly lower (1.96) in the patients without evidence for HBV infection than in the patients who were HBsAg-positive at (7.86), or before (8.85) the time of study. The significantly (P less than 0.001) higher number of B cells in the patients with chronic hepatitis of unknown etiology suggests that a different immunopathogenetic mechanism is operative in this group. A peripheral T lymphocytopenia was observed in patients with both antecedent and existent HBs-antigenemia, but not in the patients without evidence for HBV infection.
对三组患者肝脏中浸润的淋巴细胞进行分离，并鉴定为T细胞或B细胞：20例乙型肝炎表面抗原（HBsAg）阳性的急性和慢性肝炎患者、8例既往有乙型肝炎病毒（HBV）感染证据的HBsAg阴性慢性肝炎患者，以及5例既往无HBV感染证据的HBsAg阴性慢性肝炎患者。结果显示，所有类型中浸润肝脏的主要细胞均为T细胞；然而，无HBV感染证据的患者中T:B细胞比例（1.96）显著低于研究时（7.86）或研究前（8.85）HBsAg阳性的患者。病因不明的慢性肝炎患者中B细胞数量显著增多（P<0.001），提示该组存在不同的免疫发病机制。既往和现有HBs抗原血症患者均观察到外周血T淋巴细胞减少，但无HBV感染证据的患者未出现这种情况。
