Fargion S, Sangalli G, Ronchi G, Fiorelli G
J Clin Pathol. 1979 Apr;32(4):344-50. doi: 10.1136/jcp.32.4.344.
The proportions of T and B lymphocytes in the liver infiltrates of 23 patients with chronic active hepatitis have been determined. The results were compared with the values obtained from peripheral blood and with the presence of HB virus markers and alpha-fetoprotein in liver tissue. A group of patients with chronic liver disease other than chronic active hepatitis were studied as controls. In chronic active hepatitis the percentage of hepatic T cells was 49 +/- 8 SD (control patients 61 +/- 8) (P less than 0.01), whereas the percentage of B cells was 40 +/- 10 (control patients 18 +/- 8) (P less than 0.01). No correlation was observed between hepatic T and B cells and the presence of HB virus. The numbers of T cells in liver tissue was significantly higher, the numbers of B cells lower, in patients whose biopsies were positive for alpha-fetoprotein than in those whose biopsies were negative. In peripheral blood, only the patients with chronic active hepatitis and established cirrhosis presented lower absolute values of T cells, whereas surface immunoglobulin-positive lymphocytes were within the normal range.
已测定23例慢性活动性肝炎患者肝脏浸润物中T淋巴细胞和B淋巴细胞的比例。将结果与外周血所得值以及肝组织中乙肝病毒标志物和甲胎蛋白的存在情况进行了比较。研究了一组除慢性活动性肝炎外的慢性肝病患者作为对照。在慢性活动性肝炎中，肝T细胞百分比为49±8标准差（对照患者为61±8）（P<0.01），而B细胞百分比为40±10（对照患者为18±8）（P<0.01）。未观察到肝T细胞和B细胞与乙肝病毒存在之间的相关性。活检甲胎蛋白呈阳性的患者肝组织中T细胞数量显著高于活检呈阴性的患者，B细胞数量则较低。在外周血中，只有慢性活动性肝炎和确诊肝硬化患者的T细胞绝对值较低，而表面免疫球蛋白阳性淋巴细胞在正常范围内。
