Pawar Shweta, Kaja Sravani, Nag Amit
Department of Chemistry, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Hyderabad 500078, India.
ACS Omega. 2020 Apr 2;5(14):8362-8372. doi: 10.1021/acsomega.0c00883. eCollection 2020 Apr 14.
We have demonstrated the synthesis, characterization, and application of nitrogen-doped red-emitting carbon dots (NRCDs) for dual sensing of indium (In) and palladium (Pd) in water. The detection of In was associated with "turn-on" fluorescence response with a red shift, while in the presence of Pd, the fluorescence intensity of NRCDs was quenched to show a "turn-off" response. The interaction of NRCDs with the metal ions was investigated using H nuclear magnetic resonance and Fourier-transform infrared spectroscopy studies. The synthesized nanoprobes possessed good biocompatibility and photostability and were found to be suitable candidates for bioimaging due to their emission profiles in the near-infrared (NIR) window. Applicability of the as-prepared NRCDs was demonstrated in the NIR region when they were loaded in vesicle membranes with and without cations and subjected to confocal imaging successfully.
我们已经展示了氮掺杂红色发光碳点（NRCDs）的合成、表征及其在水中对铟（In）和钯（Pd）进行双传感的应用。In的检测与具有红移的“开启”荧光响应相关，而在Pd存在的情况下，NRCDs的荧光强度被猝灭以显示“关闭”响应。使用氢核磁共振和傅里叶变换红外光谱研究来探究NRCDs与金属离子的相互作用。合成的纳米探针具有良好的生物相容性和光稳定性，并且由于其在近红外（NIR）窗口的发射特性，被发现是生物成像的合适候选物。当将所制备的NRCDs加载到有或没有阳离子的囊泡膜中并成功进行共聚焦成像时，证明了其在近红外区域的适用性。
