Lucero Renee, Horowitz David
Chino Valley Medical Center
Granular parakeratosis is a rare, benign, idiopathic condition that is best categorized as a reaction pattern rather than a distinct disease. The condition presents as red-to-brown scaly-to-hyperkeratotic papules or plaques typically in intertriginous areas. The condition has been reported in patients of all ages and is more commonly seen in women than in men. Granular parakeratosis was originally thought to be a contact dermatitis to personal hygiene products such as deodorants and antiperspirants; however, cases have been reported in the absence of personal hygiene products in the affected areas which discredited contact dermatitis as the etiology. Granular parakeratosis was first described in 1991 by Northcut et al. as "axillary granular parakeratosis." Case reports have also noted granular parakeratosis in other intertriginous areas as well as non-intertriginous body areas such as the face. Granular parakeratosis typically self-resolves in one-month to one-year, and responses to various treatments have been inconsistent among reported cases.
颗粒状角化不全是一种罕见的、良性的、特发性疾病，最好将其归类为一种反应模式而非一种独特的疾病。该病表现为通常在皮肤褶皱部位出现的红色至棕色、鳞屑状至角化过度的丘疹或斑块。各年龄段患者均有该病的报道，女性比男性更常见。颗粒状角化不全最初被认为是对除臭剂和止汗剂等个人卫生用品的接触性皮炎；然而，有报道称在受影响区域没有个人卫生用品的情况下也出现了病例，这使接触性皮炎作为病因的说法不可信。颗粒状角化不全于1991年由诺思卡特等人首次描述为“腋窝颗粒状角化不全”。病例报告还指出，在其他皮肤褶皱部位以及面部等非皮肤褶皱身体部位也存在颗粒状角化不全。颗粒状角化不全通常在1个月至1年内自行消退，在已报道的病例中，对各种治疗的反应并不一致。
