Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.
Department of Neuroscience, Biomedicine and Movement Science, University of Verona, Verona, Italy.
J Clin Hypertens (Greenwich). 2018 May;20(5):918-924. doi: 10.1111/jch.13290. Epub 2018 Apr 25.
Alzheimer's disease is the most common type of dementia and one of the leading sources of disability and dependency in the elderly. Given the limited treatment options, understanding the role of modifiable risk factors implied in the disease pathogenesis is a worthwhile endeavor to limit its global burden. Recently, the variability of blood pressure has been suggested to be a significant determinant of brain alterations and a potential therapeutic target. The aim of this article is to review the clinical evidence on the association between visit-to-visit blood pressure variability and Alzheimer's disease, highlight the underlying mechanisms, and suggest future implications.
阿尔茨海默病是最常见的痴呆类型之一，也是导致老年人残疾和依赖的主要原因之一。鉴于治疗选择有限，了解疾病发病机制中可改变的风险因素的作用是限制其全球负担的一项有价值的努力。最近，血压变异性被认为是大脑改变的重要决定因素和潜在的治疗靶点。本文旨在综述血压变异性与阿尔茨海默病之间的临床证据，强调潜在机制，并提出未来的意义。
