Department of Biomass Chemistry and Engineering, Sichuan University, Sichuan 610065, China.
The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Sichuan 610065, China.
ACS Appl Mater Interfaces. 2020 May 13;12(19):22237-22245. doi: 10.1021/acsami.0c06459. Epub 2020 Apr 29.
Clinically related infection is a critical risk for human health and is usually caused by biofilm formation on medical devices. Herein, typical polyphenols, catechin (Cat), and rare-earth ions (Re) were used for self-assembled Cat-Re nanoparticles that can be facilely coated on the surface of a polyamide (PA) membrane to synergistically prevent bacterial adhesion and subsequent biofilm formation. The antibacterial adhesion feature of the assembled Cat-Re nanoparticles coated on the PA membrane surface was assessed using , one of the most common pathogenic bacteria, as probe bacteria under static and dynamic simulation flow conditions. The Cat-Re nanocoating showed excellent antibacterial and anti-adhesion activities against and successfully prevented biofilm formation on the material's surface. Regardless of the conditions, the Cat-Re nanocoating significantly suppressed the growth and attachment of and maintained >90% inhibition activity with favorable reusability and long-term stability. The results suggest that the self-assembled rare-earth-phenolic nanocoating has promising application potential in the prevention of medical device-related biofilm formation.
临床相关感染是对人类健康的重大威胁，通常是由医疗器械上的生物膜形成引起的。在此，采用典型的多酚类物质儿茶素（Cat）和稀土离子（Re）自组装成 Cat-Re 纳米粒子，可简便地涂覆在聚酰胺（PA）膜表面，协同防止细菌黏附和随后的生物膜形成。采用最常见的致病菌之一 作为探针细菌，在静态和动态模拟流动条件下，评估组装在 PA 膜表面的 Cat-Re 纳米粒子的抗菌黏附特性。Cat-Re 纳米涂层对 和 表现出优异的抗菌和抗黏附活性，成功防止了材料表面的生物膜形成。无论在何种条件下，Cat-Re 纳米涂层均能显著抑制 和 的生长和附着，具有良好的可重复使用性和长期稳定性，抑制活性保持在>90%。结果表明，自组装的稀土-酚纳米涂层在预防与医疗器械相关的生物膜形成方面具有广阔的应用前景。
