Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA; Whitehead Institute, Cambridge, MA, USA.
Trends Cancer. 2020 Sep;6(9):775-780. doi: 10.1016/j.trecan.2020.03.011. Epub 2020 Apr 17.
Tissue regeneration relies on adult stem cells (SCs) that possess the ability to self-renew and produce differentiating progeny. In an analogous manner, the development of certain cancers depends on a subset of tumor cells, called cancer stem cells (CSCs), with SC-like properties. In addition to being responsible for tumorigenesis, CSCs exhibit elevated resistance to therapy and thus drive tumor relapse post-treatment. The epithelial-mesenchymal transition (EMT) programs promote SC and CSC stemness in many epithelial tissues. Here, we provide an overview of the mechanisms underlying the relationship between stemness and EMT programs, which may represent therapeutic vulnerabilities for the treatment of cancers.
组织再生依赖于具有自我更新和产生分化后代能力的成体干细胞 (SCs)。以类似的方式，某些癌症的发展取决于称为癌症干细胞 (CSCs) 的肿瘤细胞亚群，它们具有与 SC 相似的特性。除了导致肿瘤发生外，CSCs 还表现出对治疗的高度耐药性，从而导致治疗后肿瘤复发。上皮-间充质转化 (EMT) 程序在许多上皮组织中促进 SC 和 CSC 的干性。在这里，我们提供了一个概述，介绍了干性和 EMT 程序之间关系的机制，这可能代表治疗癌症的治疗弱点。
