Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia.
School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia.
Nat Hum Behav. 2020 Aug;4(8):844-855. doi: 10.1038/s41562-020-0863-4. Epub 2020 Apr 20.
Animal neurophysiological studies have identified neural signals within dorsal frontoparietal areas that trace a perceptual decision by accumulating sensory evidence over time and trigger action upon reaching a threshold. Although analogous accumulation-to-bound signals are identifiable on extracranial human electroencephalography, their cortical origins remain unknown. Here neural metrics of human evidence accumulation, predictive of the speed of perceptual reports, were isolated using electroencephalography and related to dorsal frontoparietal network (dFPN) connectivity using diffusion and resting-state functional magnetic resonance imaging. The build-up rate of evidence accumulation mediated the relationship between the white matter macrostructure of dFPN pathways and the efficiency of perceptual reports. This association between steeper build-up rates of evidence accumulation and the dFPN was recapitulated in the resting-state networks. Stronger connectivity between dFPN regions is thus associated with faster evidence accumulation and speeded perceptual decisions. Our findings identify an integrated network for perceptual decisions that may be targeted for neurorehabilitation in cognitive disorders.
动物神经生理学研究已经确定了背侧额顶区域内的神经信号，这些信号通过随时间积累感官证据来追踪感知决策，并在达到阈值时触发行动。尽管在体外人类脑电图上可以识别出类似的累积到边界信号，但它们的皮质起源仍然未知。在这里，使用脑电图分离了人类证据积累的神经指标，这些指标可以预测感知报告的速度，并使用扩散和静息状态功能磁共振成像将其与背侧额顶网络（dFPN）的连通性相关联。证据积累的构建速率介导了 dFPN 路径的白质宏观结构与感知报告效率之间的关系。证据积累的构建速率越快，与 dFPN 的关联性越强，这一关联在静息状态网络中得到了重现。因此，dFPN 区域之间更强的连通性与更快的证据积累和更快的感知决策相关。我们的发现确定了一个用于感知决策的综合网络，该网络可能成为认知障碍神经康复的目标。
