Department of Health Sciences, Faculty of Science, University of Mauritius, Réduit, Mauritius.
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
Drug Dev Res. 2020 Sep;81(6):671-684. doi: 10.1002/ddr.21670. Epub 2020 Apr 20.
Globally, approximately 12% of the population is inflicted by various types of urolithiasis. Standard treatments are available both to avert and treat urolithiasis, but with significant adverse side effects. Pentacyclic triterpenes represent a group of naturally occurring compounds which holds immense potential as therapeutic for treating kidney stone. This review aims to provide an integrative description on how pentacyclic triterpenes can effectively treat calcium oxalate urolithiasis through various mechanisms such as antioxidant, anti-inflammatory, diuretic, and angiotensin-converting enzyme inhibition. Some of the pentacylic triterpenes which shows promising activities include lupeol, oleanolic acid, betulin, and taraxasterol. Moreover, future perspectives in the development of pentacyclic triterpenes in formulations/drugs for urinary stone prevention are highlighted. It is anticipated that compiled information would serve as a scientific baseline to advocate further investigations on the potential of pentacyclic triterpenes in urolithiasis remediation.
全球约有 12%的人口患有各种类型的尿路结石。有标准的治疗方法可以预防和治疗尿路结石，但有明显的不良反应。五环三萜是一组天然存在的化合物，具有治疗肾结石的巨大潜力。本综述旨在综合描述五环三萜如何通过抗氧化、抗炎、利尿和血管紧张素转换酶抑制等多种机制有效治疗草酸钙尿路结石。一些表现出有希望的活性的五环三萜包括羽扇豆醇、齐墩果酸、白桦脂醇和蒲公英甾醇。此外，还强调了在开发用于预防尿路结石的制剂/药物中五环三萜的未来展望。预计综合信息将作为科学基础，倡导进一步研究五环三萜在尿路结石修复中的潜力。
