Sección de estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico.
Hospital Regional de Alta Especialidad de la Península de Yucatán, Yucatán, Mérida 97130, Mexico.
Molecules. 2022 Mar 21;27(6):2008. doi: 10.3390/molecules27062008.
Urolithiasis (UL) involves the formation of stones in different parts of the urinary tract. UL is a health problem, and its prevalence has increased considerably in developing countries. Several regions use plants in traditional medicine as an alternative in the treatment or prevention of UL. Mexico has known about the role of traditional medicine in the management of urinary stones. Mexican traditional medicine uses plants such as L., , , L., (L.) , () , () , and L. These plants contain different bioactive compounds, including polyphenols, flavonoids, phytosterols, saponins, furanochromones, alkaloids, and terpenoids, which could be effective in preventing the process of stone formation. Evidence suggests that their beneficial effects might be associated with litholytic, antispasmodic, and diuretic activities, as well as an inhibitory effect on crystallization, nucleation, and aggregation of crystals. The molecular mechanisms involving these effects could be related to antioxidant, anti-inflammatory, and antimicrobial properties. Thus, the review aims to summarize the preclinical evidence, bioactive compounds, and molecular mechanisms of the plants used in Mexican traditional medicine for the management of UL.
尿石症 (UL) 涉及尿路不同部位结石的形成。UL 是一个健康问题，在发展中国家其发病率显著增加。一些地区在传统医学中使用植物作为 UL 治疗或预防的替代方法。墨西哥了解传统医学在管理尿路结石方面的作用。墨西哥传统医学使用植物，如 L.、、、L.、()、()、()和 L. 这些植物含有不同的生物活性化合物，包括多酚、类黄酮、植物甾醇、皂苷、呋喃色酮、生物碱和萜类化合物，这些化合物可能有效预防结石形成过程。有证据表明，它们的有益作用可能与溶石、抗痉挛和利尿活性以及对晶体结晶、成核和聚集的抑制作用有关。涉及这些作用的分子机制可能与抗氧化、抗炎和抗菌特性有关。因此，本综述旨在总结用于墨西哥传统医学治疗 UL 的植物的临床前证据、生物活性化合物和分子机制。
