病例报告：两名旅行者因感染 而罹患皮肤利什曼病，米替福新治疗有效。
Case Report: Cutaneous Leishmaniasis due to in Two Travelers Successfully Treated with Miltefosine.
机构信息
1Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado.
2Division of Pathology, University of Colorado School of Medicine, Aurora, Colorado.
出版信息
Am J Trop Med Hyg. 2020 Sep;103(3):1081-1084. doi: 10.4269/ajtmh.20-0086.
Abstract
We present two cases of () in returning travelers from Central America successfully treated with miltefosine. The couple presented with ulcerative skin lesions nonresponsive to antibiotics. Skin biopsy with polymerase chain reaction (PCR) revealed () To prevent the development of mucosal disease and avoid the inconvenience of parental therapy, we treated both patients with oral miltefosine. We suggest that miltefosine represents an important therapeutic alternative in the treatment of cutaneous lesions caused by and in preventing mucosal involvement.
摘要
我们报告两例从中美洲旅行归来的 () 患者，他们均经米替福新成功治疗。这对夫妇表现为对抗生素无反应的溃疡性皮肤损伤。皮肤活检聚合酶链反应（PCR）显示 () 为了预防黏膜疾病的发生并避免父母治疗的不便，我们对这两名患者均采用口服米替福新进行治疗。我们建议米替福新是治疗 () 引起的皮肤损伤和预防黏膜受累的重要治疗选择。
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2
Cutaneous Leishmaniasis: Updates in Diagnosis and Management.皮肤利什曼病：诊断与管理的最新进展。
Infect Dis Clin North Am. 2019 Mar;33(1):101-117. doi: 10.1016/j.idc.2018.10.004.
3
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4
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9
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10
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