Li Mingli, Fang Jing, Gao Yang, Wu Yali, Shen Lili, Yusubujiang Yiming, Luo Jin
Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; The Mental Rehabilitation Centers, Karamay Municipal People's Hospital, Karamay, Xinjiang 830054, China.
The Mental Rehabilitation Centers, Karamay Municipal People's Hospital, Karamay, Xinjiang 830054, China.
Asian J Psychiatr. 2020 Jun;51:102046. doi: 10.1016/j.ajp.2020.102046. Epub 2020 Apr 1.
Neurocognitive impairment is one of the core symptoms in schizophrenia and poses a great challenge to effective treatment. Sixty-one long-term hospitalized patients with schizophrenia were recruited and randomly assigned to two groups: Baduanjin exercise and brisk walking. Patients in the Baduanjin group received 24 weeks of Baduanjin training (5 days/week, 40 min/day), while patients in the brisk walking group received 24 weeks of brisk walking (5 days/week, 40 min/day). Scores on the Wechsler Memory Scale, Digit Symbol Substitution Test (DSST), and the positive and negative syndrome scale were used to evaluate the logical memory (LM), processing speed, and clinical symptoms of all participants, while the score of Trail Making Test-A (TMT-A) was applied to assess the visual attention and graphomotor speed, at baseline and the 16th week and 24th week of intervention. The one-way repeated measures analysis of variance (ANOVA) was used to test the differences in neurocognitive changes between the two groups. Repeated measures ANOVA showed significant differences between the two groups in the LM immediate (F = 6.21, p = 0.003) and LM delayed (F=5.60, p = 0.005) scores, but not in the completion times of TMT-A (F=.22, p = 0.806) or DSST scores (F=0.97, p = 0.328). A significant effect of time was also detected in the LM immediate (F=10.24, p = 0.000) and LM delayed (F=4.93, p = 0.009) scores and in the completion time of the TMT-A (F=33.10, p = 0.000), but not in the DSST scores (F=2.12, p = 0.122). Baduanjin exercise could improve logical memory in the long-term hospitalized patients with schizophrenia.
神经认知障碍是精神分裂症的核心症状之一，对有效治疗构成巨大挑战。招募了61名长期住院的精神分裂症患者，并将他们随机分为两组：八段锦锻炼组和快走组。八段锦组患者接受为期24周的八段锦训练（每周5天，每天40分钟），而快走组患者接受为期24周的快走训练（每周5天，每天40分钟）。使用韦氏记忆量表、数字符号替换测验（DSST）以及阳性和阴性症状量表的得分来评估所有参与者的逻辑记忆（LM）、处理速度和临床症状，同时在干预的基线、第16周和第24周应用连线测验A（TMT-A）的得分来评估视觉注意力和书写运动速度。采用单因素重复测量方差分析（ANOVA）来检验两组之间神经认知变化的差异。重复测量方差分析显示，两组在即时逻辑记忆（F = 6.21，p = 0.003）和延迟逻辑记忆（F = 5.60，p = 0.005）得分上存在显著差异，但在TMT-A的完成时间（F = 0.22，p = 0.806）或DSST得分（F = 0.97，p = 0.328）上没有显著差异。在即时逻辑记忆（F = 10.24，p = 0.000）和延迟逻辑记忆（F = 4.93，p = 0.009）得分以及TMT-A的完成时间（F = 33.10，p = 0.000）上也检测到了显著的时间效应，但在DSST得分上没有（F = 2.12，p = 0.122）。八段锦锻炼可以改善长期住院的精神分裂症患者的逻辑记忆。
