Sabot G, Bagnato A, Frigerio G
Int J Clin Pharmacol Biopharm. 1977 Apr;15(4):181-3.
A double-blind cross-over trial was carried out to evaluate the antitussive activity of viminol p-hydroxybenzoate; the comparison was done with three preparations: a placebo and the drug at two doses, 70 and 140 mg respectively. The responses were scored hourly up to 4 hours after the administration of single doses in the morning to subjects with persistent cough. The highest dose of viminol showed a definite antitussive activity, whereas the lowest did not differ from the placebo. The antitussive effect appears clinically useful for the treatment of cough, but further studies are indicated to define optimal dosage schedules.
进行了一项双盲交叉试验，以评估维米诺对羟基苯甲酸酯的镇咳活性；与三种制剂进行了比较：一种安慰剂以及分别为70毫克和140毫克的两种剂量的药物。在早晨给持续性咳嗽患者单次给药后，每小时记录反应，直至4小时。维米诺的最高剂量显示出明确的镇咳活性，而最低剂量与安慰剂无差异。镇咳作用在临床上似乎对咳嗽治疗有用，但需要进一步研究以确定最佳给药方案。
