Faculty of Food, Nutrition and Hospitality Sciences, Hochschule Niederrhein, University of Applied Sciences, Rheydter Str. 277, 41065 Mönchengladbach, Germany.
Nutrients. 2020 Apr 17;12(4):1134. doi: 10.3390/nu12041134.
Cardiometabolic diseases are a leading global health challenge. Their incidence as well as progression is strongly affected by diet. Consumption of ), an edible oyster mushroom rich in functional ingredients (e.g., β-glucans), may improve glucose and lipid metabolism, blood pressure, body weight and appetite sensations. Hence, this systematic review aimed to provide an overview on the effects of intake on cardiometabolic parameters from clinical trials, taking into account risk of bias (RoB). Relevant studies were investigated for details with consideration of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. The Cochrane Collaboration's tool was used to assess the RoB. In total, eight trials included observed beneficial effects of intake on glucose metabolism (reduction in fasting and/or 2 h postprandial glucose) and lipids (decrease in total cholesterol, LDL-cholesterol and/or triglycerides), and some found a reduction in blood pressure. In contrast, body weight did not change. Appetite sensations were not assessed. In most studies, the RoB was high or unclear due to methodological weaknesses and/or inadequate reporting. Thus, intake may improve cardiometabolic health, but evidence for this is low. Hence, further clinical trials with an adequate study design are warranted to validate these suggestions.
心血管代谢疾病是全球主要的健康挑战之一。其发病率和进展受到饮食的强烈影响。食用富含功能性成分（如β-葡聚糖）的可食用牡蛎菇，可能改善葡萄糖和脂质代谢、血压、体重和食欲感知。因此，本系统评价旨在从临床试验中概述 摄入对心血管代谢参数的影响，并考虑偏倚风险（RoB）。详细研究了相关研究，并考虑了系统评价和荟萃分析的首选报告项目（PRISMA）指南。使用 Cochrane 协作工具评估 RoB。共有八项试验观察到 摄入对葡萄糖代谢（空腹和/或餐后 2 小时血糖降低）和脂质（总胆固醇、LDL-胆固醇和/或甘油三酯降低）的有益影响，一些试验发现血压降低。相比之下，体重没有变化。未评估食欲感知。在大多数研究中，由于方法学上的弱点和/或报告不充分，RoB 较高或不明确。因此，需要进一步进行设计合理的临床试验来验证这些建议。
