评估精油和高渗盐水作为杀血吸虫剂在诱导兔硬化性胆管炎中的作用。
Evaluation the Effects of Essential Oil and Hypertonic Saline as Scolicidal Agents in Induction of Sclerosing Cholangitis in Rabbits.
作者信息
Hosseini Seyed Vahid, Al-Qanbar Maytham Hameed, Khazraei Hajar, Khodaei Shahin, Mokhtari Maral, Iranpour Pooya
机构信息
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Kufa Univerisity of Medical Sciences, Kufa, Iraq.
出版信息
Adv Biomed Res. 2020 Feb 28;9:9. doi: 10.4103/abr.abr_210_19. eCollection 2020.
BACKGROUND
There are several scolicidal agents for inactivation of hydatid cyst protoscolices during surgery, but most of them are associated with adverse side effects such as sclerosing cholangitis (SC) and liver necrosis. The present study aimed to evaluate the adverse effects of essential oil to induce SC in animal models.
MATERIALS AND METHODS
Eighteen rabbits weighting 2000-3500 g were included in three groups for this study. About 0.3 ml of essential oil (1%), or 5% hypertonic saline, or normal saline was injected for 5 min in the gallbladder. After 4 months, the liver, common bile duct, and duodenum were resected and immediately sent for cholangiography and pathologic studies.
RESULTS
According to pathological studies, inflammation is more common in and hypertonic saline groups. Due to cholangiographic studies, stricture was slightly higher in the hypertonic saline group than the group.
CONCLUSION
Thus, 1% essential oil is at least as safe as 5% hypertonic saline, but for clinical uses, it must be confirmed with further studies.
背景
手术期间有几种杀包虫剂可使包虫囊肿原头节失活，但其中大多数都伴有诸如硬化性胆管炎（SC）和肝坏死等不良副作用。本研究旨在评估精油在动物模型中诱发SC的不良反应。
材料与方法
本研究将18只体重2000 - 3500克的兔子分为三组。在胆囊中注入约0.3毫升精油（1%）、或5%高渗盐水、或生理盐水5分钟。4个月后，切除肝脏、胆总管和十二指肠，并立即送去进行胆管造影和病理研究。
结果
根据病理研究，精油组和高渗盐水组炎症更为常见。由于胆管造影研究，高渗盐水组的狭窄发生率略高于精油组。
结论
因此，1%精油至少与5%高渗盐水一样安全，但对于临床应用，必须通过进一步研究加以证实。
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