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黑种草籽不同提取物对包虫囊肿原头节的体外致死作用。

In vitro lethal effects of various extracts of Nigella sativa seed on hydatid cyst protoscoleces.

作者信息

Mahmoudvand Hossein, Asadi Arash, Harandi Majid Fasihi, Sharififar Fariba, Jahanbakhsh Sareh, Dezaki Ebrahimm Saedi

机构信息

Research Center for Tropical and Infectious Diseases, Kerman University of Medical Science, Kerman, Iran ; Research Center for Hydatid Disease in Iran, Kerman University of Medical Sciences, Kerman, Iran.

Department of Medical Parasitology and Mycology, Kerman University of Medical Sciences Kerman, Iran.

出版信息

Iran J Basic Med Sci. 2014 Dec;17(12):1001-6.

PMID:25859304
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4387222/
Abstract

OBJECTIVES

There are several scolicidal agents for inactivation of hydatid cyst protoscolices during surgery, but most of them are associated with adverse side effects such as sclerosing cholangitis and liver necrosis. The present study was aimed to evaluate scolicidal effects of various extracts of Nigella sativa seeds against protoscoleces of hydatid cyst in an in vitro model.

MATERIALS AND METHODS

Protoscoleces were aseptically aspirated from naturally infected livers of sheep and goats. Various concentrations of the different extracts of N. sativa (5 to 50 mg/ml) were used for 5 to 60 min. Viability of protoscoleces was confirmed by 0.1% eosin staining.

RESULTS

The findings exhibited that methanolic extract at the concentration of 50 mg/ml after 10 min of incubation, and aqueous extract at the concentration of 50 mg/ml after 30 min of incubation can kill 100% of protoscoleces. In addition, all of experiments revealed dose-dependent and also time-dependent scolicidal effect of various extracts of N. sativa on the protoscoleces of hydatid cyst.

CONCLUSION

The results of the present study demonstrated that N. sativa may be a natural source for the production of new scolicidal agent for use in hydatid cyst surgery. However, further studies will be required to evaluate scolicidal effects of N. sativa in the in vivo model.

摘要

目的

手术过程中有多种杀头节剂可使包虫囊肿原头节失活，但其中大多数都伴有诸如硬化性胆管炎和肝坏死等不良副作用。本研究旨在评估黑种草籽的各种提取物在体外模型中对包虫囊肿原头节的杀头节效果。

材料与方法

从自然感染的绵羊和山羊肝脏中无菌吸出原头节。使用不同浓度（5至50毫克/毫升）的黑种草提取物处理5至60分钟。通过0.1%伊红染色确认原头节的活力。

结果

研究结果显示，50毫克/毫升的甲醇提取物孵育10分钟后，以及50毫克/毫升的水提取物孵育30分钟后，均可杀死100%的原头节。此外，所有实验均表明黑种草的各种提取物对包虫囊肿原头节具有剂量依赖性和时间依赖性的杀头节作用。

结论

本研究结果表明，黑种草可能是生产用于包虫囊肿手术的新型杀头节剂的天然来源。然而，还需要进一步研究以评估黑种草在体内模型中的杀头节效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8eb/4387222/b6ba425787d1/IJBMS-17-1001-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8eb/4387222/f1a1361d7314/IJBMS-17-1001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8eb/4387222/599f4e2563ce/IJBMS-17-1001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8eb/4387222/4e8d85fe9c10/IJBMS-17-1001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8eb/4387222/b6ba425787d1/IJBMS-17-1001-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8eb/4387222/f1a1361d7314/IJBMS-17-1001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8eb/4387222/599f4e2563ce/IJBMS-17-1001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8eb/4387222/4e8d85fe9c10/IJBMS-17-1001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8eb/4387222/b6ba425787d1/IJBMS-17-1001-g004.jpg

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