Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island.
Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York.
JAMA Netw Open. 2020 Apr 1;3(4):e203711. doi: 10.1001/jamanetworkopen.2020.3711.
Treatment with methadone or buprenorphine is the current standard of care for opioid use disorder. Given the paucity of research identifying which patients will respond best to which medication, both medications should be accessible to all patients so that patients can determine which works best for them. However, given differences in the historical contexts of their initial implementation, access to each of these medications may vary along racial/ethnic lines.
To examine the extent to which capacity to provide methadone and buprenorphine vary with measures of racial/ethnic segregation.
DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study included all counties and county-equivalent divisions in the US in 2016. Data on racial/ethnic population distribution were derived from the American Community Survey, and data on locations of facilities providing methadone and buprenorphine were obtained from Substance Abuse and Mental Health Services Administration databases. Data were analyzed from August 22, 2018, to September 11, 2019.
Two county-level measures of racial/ethnic segregation, including dissimilarity (representing the proportion of African American or Hispanic/Latino residents who would need to move census tracts to achieve a uniform spatial distribution of the population by race/ethnicity) and interaction (representing the probability that an African American or Hispanic/Latino resident will interact with a white resident and vice versa, assuming random mixing across census tracts).
County-level capacity to provide methadone or buprenorphine, defined as the number of facilities providing a medication per 100 000 population.
Among 3142 US counties, there were 1698 facilities providing methadone (0.6 facilities per 100 000 population) and 18 868 facilities providing buprenorphine (5.9 facilities per 100 000 population). Each 1% decrease in probability of interaction of an African American resident with a white resident was associated with 0.6 more facilities providing methadone per 100 000 population. Similarly, each 1% decrease in probability of interaction of a Hispanic/Latino resident with a white resident was associated with 0.3 more facilities providing methadone per 100 000 population. Each 1% decrease in the probability of interaction of a white resident with an African American resident was associated with 8.17 more facilities providing buprenorphine per 100 000 population. Similarly, each 1% decrease in the probability of interaction of a white resident with a Hispanic/Latino resident was associated with 1.61 more facilities providing buprenorphine per 100 000 population.
These findings suggest that the racial/ethnic composition of a community was associated with which medications residents would likely be able to access when seeking treatment for opioid use disorder. Reforms to existing regulations governing the provisions of these medications are needed to ensure that both medications are equally accessible to all.
美沙酮或丁丙诺啡的治疗是目前阿片类药物使用障碍的标准治疗方法。鉴于研究确定哪些患者对哪种药物反应最好的研究很少,这两种药物都应该提供给所有患者,以便患者可以确定哪种药物最适合他们。然而,鉴于它们最初实施的历史背景存在差异,获得这两种药物的途径可能因种族/族裔而有所不同。
研究种族/族裔隔离程度与美沙酮和丁丙诺啡提供能力之间的关系。
设计、地点和参与者:本横断面研究包括 2016 年美国所有县和相当于县的分区。种族/族裔人口分布数据来自美国社区调查,提供美沙酮和丁丙诺啡的设施位置数据来自药物滥用和心理健康服务管理局数据库。数据分析于 2018 年 8 月 22 日至 2019 年 9 月 11 日进行。
两种县一级的种族/族裔隔离程度指标,包括不相似性(代表需要搬迁的非裔美国人和西班牙裔/拉丁裔居民的比例,以实现按种族/族裔划分的人口的均匀空间分布)和相互作用(代表非裔美国人和西班牙裔/拉丁裔居民与白人居民互动的概率,以及反之亦然,假设在普查区内随机混合)。
县一级提供美沙酮或丁丙诺啡的能力,定义为每 10 万人提供的设施数量。
在 3142 个美国县中,有 1698 个提供美沙酮的设施(每 10 万人中有 0.6 个设施)和 18868 个提供丁丙诺啡的设施(每 10 万人中有 5.9 个设施)。非裔美国居民与白人居民相互作用的概率每降低 1%,每 10 万人中提供的美沙酮设施就会增加 0.6 个。同样,西班牙裔/拉丁裔居民与白人居民相互作用的概率每降低 1%,每 10 万人中提供的美沙酮设施就会增加 0.3 个。白人居民与非裔美国居民相互作用的概率每降低 1%,每 10 万人中提供的丁丙诺啡设施就会增加 8.17 个。同样,白人居民与西班牙裔/拉丁裔居民相互作用的概率每降低 1%,每 10 万人中提供的丁丙诺啡设施就会增加 1.61 个。
这些发现表明,社区的种族/族裔构成与居民在寻求阿片类药物使用障碍治疗时可能能够获得的药物有关。需要对管理这些药物提供的现有法规进行改革,以确保两种药物都能平等地提供给所有人。