Department of Oral Medicine and radiology, Panineeya institute of dental sciences, Hyderabad.
Department of Oral Pathology and Microbiology, PMVIDS, Hyderabad.
J Popul Ther Clin Pharmacol. 2020 Apr 6;27(2):e19-e27. doi: 10.15586/jptcp.v27i2.667.
Oral lichen planus (OLP) is a T cell-mediated chronic autoimmune disorder directed against antigens secreted by the basal cell layer, with an incidence of 0.02-0.22% in Indian population and showing female predilection. Stress is considered one of the etiological factors in the causation, progression, and recurrence of this disease.
To evaluate the levels of serum cortisol, anxiety, and depression in patients with symptomatic OLP and to correlate the levels of serum cortisol with anxiety and depression.
Sixty subjects were categorized into two groups. Group A: 30 adults with no history of OLP and no psychological history of anxiety and depression. Group B: 30 patients with clinically and histopathologically diagnosed symptomatic OLP. The subjects in both groups were evaluated for anxiety and depression levels using the Hospital Anxiety and Depression Scale (HADS) questionnaire and serum cortisol levels (8-9 am sample) using the chemiluminiscence method.
Higher depression and anxiety levels were significantly associated with group B with significant P values (P < 0.0001 and <0.0002 respectively) when compared with group A; higher mean serum cortisol levels were seen in group B compared with group A, with P < 0.0001. In group A, a positive correlation was found between depression, anxiety, and serum cortisol levels with non-significant P-value. In group B, a positive correlation was found between depression, anxiety, and serum cortisol levels with a significant P value (P < 0.0001).
Increased levels of depression and anxiety with increased serum cortisol levels were observed in subjects with OLP.
口腔扁平苔藓（OLP）是一种针对基底层分泌抗原的 T 细胞介导的慢性自身免疫性疾病，在印度人群中的发病率为 0.02%-0.22%，并显示出女性倾向。压力被认为是导致这种疾病发生、进展和复发的病因之一。
评估有症状的 OLP 患者的血清皮质醇、焦虑和抑郁水平，并将血清皮质醇水平与焦虑和抑郁相关联。
将 60 名受试者分为两组。A 组：30 名无 OLP 病史且无焦虑和抑郁心理史的成年人。B 组：30 名经临床和组织病理学诊断为有症状的 OLP 患者。使用医院焦虑和抑郁量表（HADS）问卷评估两组受试者的焦虑和抑郁水平，并使用化学发光法检测血清皮质醇水平（8-9 am 样本）。
与 A 组相比，B 组的抑郁和焦虑水平显著升高（P<0.0001 和 P<0.0002），与 B 组有显著差异；B 组的血清皮质醇水平明显高于 A 组，P<0.0001。在 A 组中，抑郁、焦虑和血清皮质醇水平之间存在正相关，但 P 值无统计学意义。在 B 组中，抑郁、焦虑和血清皮质醇水平之间存在正相关，P 值有统计学意义（P<0.0001）。
在 OLP 患者中，观察到抑郁和焦虑水平升高，同时血清皮质醇水平升高。
