Immunopathology Laboratory, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA
mSphere. 2020 Apr 22;5(2):e00344-20. doi: 10.1128/mSphere.00344-20.
Since its emergence in December 2019, it took only a couple of months for an outbreak of the novel coronavirus disease 2019 (COVID-19) to be declared a pandemic by the World Health Organization (WHO). This along with the highly infectious nature of the disease and the associated mortality call for particular attention to the underlying (immuno)pathomechanism(s). The latter will inform case management and vaccine design. Unravelling these mechanisms can assist basic scientists, laboratory medicine practitioners, clinicians, public health practitioners, funding agencies, and health care policymakers in responding to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.
自 2019 年 12 月出现以来，新型冠状病毒病（COVID-19）的爆发仅用了几个月的时间就被世界卫生组织（WHO）宣布为大流行。这与疾病的高度传染性以及相关死亡率有关，需要特别注意潜在的（免疫）发病机制。后者将为病例管理和疫苗设计提供信息。揭示这些机制可以帮助基础科学家、实验室医学从业者、临床医生、公共卫生从业者、资助机构和医疗保健政策制定者应对严重急性呼吸系统综合症冠状病毒 2（SARS-CoV-2）大流行。
