"Carol Davila" University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021 Bucharest, Romania.
"Victor Babes" Clinical Hospital for Infectious Diseases, 281 Mihai Bravu, 030303 Bucharest, Romania.
J Immunol Res. 2020 Apr 6;2020:5701639. doi: 10.1155/2020/5701639. eCollection 2020.
Cutaneous squamous cell carcinoma (cSCC) is a common form of skin cancer with a complex but not fully understood pathogenesis. Recent research suggests the role of beta human papillomavirus (HPV) types and HPV-associated inflammatory processes in cSCC development. Beta HPV types are components of the normal flora; however, under the influence of certain cofactors, the virus may trigger a malignant process. Dysregulation of the immune system (chronic inflammation and immunosuppression), environmental factors (ultraviolet radiation), and genetic factors are the most important cofactors involved in beta HPV-related carcinogenesis. In addition, the oncoproteins E6 and E7 of beta HPV types differ biochemically from their counterparts in the structure of alpha HPV types, resulting in different mechanisms of action in carcinogenesis. The aim of our manuscript is to present an updated point of view on the involvement of beta HPV types in cSCC pathogenesis.
皮肤鳞状细胞癌（cSCC）是一种常见的皮肤癌，其发病机制复杂但尚未完全阐明。最近的研究表明，β型人乳头瘤病毒（HPV）类型及其与 HPV 相关的炎症过程在 cSCC 的发展中起作用。β型 HPV 类型是正常菌群的组成部分；然而，在某些协同因素的影响下，病毒可能引发恶性过程。免疫系统失调（慢性炎症和免疫抑制）、环境因素（紫外线辐射）和遗传因素是参与β型 HPV 相关致癌作用的最重要协同因素。此外，β型 HPV 类型的 E6 和 E7 癌蛋白在生化上与 α 型 HPV 类型的相应蛋白不同，导致致癌作用的不同机制。我们的手稿旨在介绍β型 HPV 类型在 cSCC 发病机制中的参与的最新观点。
