Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043, Orbassano, Italy.
Department of Oncology, University of Turin, Regione Gonzole 10, 10043, Orbassano, Italy.
Cell Mol Life Sci. 2020 Nov;77(22):4449-4458. doi: 10.1007/s00018-020-03524-9. Epub 2020 Apr 22.
The onco-suppressor p53 is a transcription factor that regulates a wide spectrum of genes involved in various cellular functions including apoptosis, cell cycle arrest, senescence, autophagy, DNA repair and angiogenesis. p53 and NF-κB generally have opposing effects in cancer cells. While p53 activity is associated with apoptosis induction, the stimulation of NF-κB has been demonstrated to promote resistance to programmed cell death. Although the transcription factor NF-κB family is considered as the master regulator of cancer development and maintenance, it has been mainly studied in relation to its ability to regulate p53. This has revealed the importance of the crosstalk between NF-κB, p53 and other crucial cell signaling pathways. This review analyzes the various mechanisms by which NF-κB regulates the activity of p53 and the role of p53 on NF-κB activity.
抑癌基因 p53 是一种转录因子，可调节广泛参与各种细胞功能的基因，包括细胞凋亡、细胞周期停滞、衰老、自噬、DNA 修复和血管生成。p53 和 NF-κB 通常在癌细胞中具有相反的作用。虽然 p53 活性与细胞凋亡诱导有关，但 NF-κB 的刺激已被证明可促进对程序性细胞死亡的抵抗。尽管转录因子 NF-κB 家族被认为是癌症发展和维持的主要调节剂，但主要是研究其调节 p53 的能力。这揭示了 NF-κB、p53 和其他关键细胞信号通路之间串扰的重要性。本综述分析了 NF-κB 调节 p53 活性的各种机制以及 p53 对 NF-κB 活性的作用。
