P53 与 NF-κB：核因子-κB 在调节 p53 活性中的作用及其相反。
P53 vs NF-κB: the role of nuclear factor-kappa B in the regulation of p53 activity and vice versa.
机构信息
Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043, Orbassano, Italy.
Department of Oncology, University of Turin, Regione Gonzole 10, 10043, Orbassano, Italy.
出版信息
Cell Mol Life Sci. 2020 Nov;77(22):4449-4458. doi: 10.1007/s00018-020-03524-9. Epub 2020 Apr 22.
Abstract
The onco-suppressor p53 is a transcription factor that regulates a wide spectrum of genes involved in various cellular functions including apoptosis, cell cycle arrest, senescence, autophagy, DNA repair and angiogenesis. p53 and NF-κB generally have opposing effects in cancer cells. While p53 activity is associated with apoptosis induction, the stimulation of NF-κB has been demonstrated to promote resistance to programmed cell death. Although the transcription factor NF-κB family is considered as the master regulator of cancer development and maintenance, it has been mainly studied in relation to its ability to regulate p53. This has revealed the importance of the crosstalk between NF-κB, p53 and other crucial cell signaling pathways. This review analyzes the various mechanisms by which NF-κB regulates the activity of p53 and the role of p53 on NF-κB activity.
摘要
抑癌基因 p53 是一种转录因子，可调节广泛参与各种细胞功能的基因，包括细胞凋亡、细胞周期停滞、衰老、自噬、DNA 修复和血管生成。p53 和 NF-κB 通常在癌细胞中具有相反的作用。虽然 p53 活性与细胞凋亡诱导有关，但 NF-κB 的刺激已被证明可促进对程序性细胞死亡的抵抗。尽管转录因子 NF-κB 家族被认为是癌症发展和维持的主要调节剂，但主要是研究其调节 p53 的能力。这揭示了 NF-κB、p53 和其他关键细胞信号通路之间串扰的重要性。本综述分析了 NF-κB 调节 p53 活性的各种机制以及 p53 对 NF-κB 活性的作用。
相似文献
1
P53 vs NF-κB: the role of nuclear factor-kappa B in the regulation of p53 activity and vice versa.P53 与 NF-κB：核因子-κB 在调节 p53 活性中的作用及其相反。
Cell Mol Life Sci. 2020 Nov;77(22):4449-4458. doi: 10.1007/s00018-020-03524-9. Epub 2020 Apr 22.
2
Transcriptional cross talk between NF-kappaB and p53.核因子κB与p53之间的转录相互作用
Mol Cell Biol. 1999 May;19(5):3485-95. doi: 10.1128/MCB.19.5.3485.
3
Reciprocal regulation of p53 and NF-κB by diacylglycerol kinase ζ.二酰甘油激酶ζ对p53和核因子κB的相互调节
Adv Biol Regul. 2016 Jan;60:15-21. doi: 10.1016/j.jbior.2015.09.009. Epub 2015 Oct 19.
4
Effects of IkappaBalpha and its mutants on NF-kappaB and p53 signaling pathways.IkappaBalpha及其突变体对核因子-κB和p53信号通路的影响。
World J Gastroenterol. 2006 Nov 7;12(41):6658-64. doi: 10.3748/wjg.v12.i41.6658.
5
Role of NF-kappaB in p53-mediated programmed cell death.核因子κB在p53介导的程序性细胞死亡中的作用。
Nature. 2000 Apr 20;404(6780):892-7. doi: 10.1038/35009130.
6
Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage.核因子-κB调节暴露于DNA损伤的神经元中的p53反应。
J Neurosci. 2004 Mar 24;24(12):2963-73. doi: 10.1523/JNEUROSCI.0155-04.2004.
7
Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons.p53与核因子-κB转录活性的相互抑制决定神经元的细胞存活或死亡。
J Neurosci. 2003 Sep 17;23(24):8586-95. doi: 10.1523/JNEUROSCI.23-24-08586.2003.
8
Overexpression of the wild-type p53 gene inhibits NF-kappaB activity and synergizes with aspirin to induce apoptosis in human colon cancer cells.野生型p53基因的过表达抑制核因子-κB活性，并与阿司匹林协同作用诱导人结肠癌细胞凋亡。
Oncogene. 2000 Feb 10;19(6):726-36. doi: 10.1038/sj.onc.1203383.
9
Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence.p53和Rb的调控将替代性NF-κB途径与EZH2表达及细胞衰老联系起来。
PLoS Genet. 2014 Sep 25;10(9):e1004642. doi: 10.1371/journal.pgen.1004642. eCollection 2014 Sep.
10
Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells.I 类组蛋白去乙酰化酶调节癌细胞中的 p53/NF-κB 相互作用。
Cell Signal. 2017 Jan;29:218-225. doi: 10.1016/j.cellsig.2016.11.002. Epub 2016 Nov 9.
引用本文的文献
1
Natural Products from Chinese Medicine Targeting NF-κB Signaling: Emerging Therapeutic Avenues for Neurodegenerative Diseases.靶向NF-κB信号通路的中药天然产物：神经退行性疾病的新兴治疗途径
Drug Des Devel Ther. 2025 Sep 10;19:8135-8159. doi: 10.2147/DDDT.S534706. eCollection 2025.
2
The Multifaceted Role of p53 in Cancer Molecular Biology: Insights for Precision Diagnosis and Therapeutic Breakthroughs.p53在癌症分子生物学中的多面角色：精准诊断与治疗突破的见解
Biomolecules. 2025 Jul 27;15(8):1088. doi: 10.3390/biom15081088.
3
Orientia tsutsugamushi modulates p53, the cell cycle, and genotoxicity to maintain its intracellular niche.恙虫病东方体调节p53、细胞周期和基因毒性以维持其细胞内生态位。
Nat Commun. 2025 Aug 19;16(1):7728. doi: 10.1038/s41467-025-63149-z.
4
Antimicrobial and Anticancer Activities of Probio87 Isolated from Human Breast Milk.从人乳中分离出的Probio87的抗菌和抗癌活性
Nutrients. 2025 Aug 5;17(15):2554. doi: 10.3390/nu17152554.
5
Cellular defense mechanisms against asbestos fibers.细胞对石棉纤维的防御机制。
Front Public Health. 2025 May 14;13:1566473. doi: 10.3389/fpubh.2025.1566473. eCollection 2025.
6
Jingtian granule alleviates adenine-induced renal fibrosis in mice through SIRT3-Mediated deacetylation of P53.景天颗粒通过SIRT3介导的P53去乙酰化减轻腺嘌呤诱导的小鼠肾纤维化。
Front Pharmacol. 2025 Mar 12;16:1526414. doi: 10.3389/fphar.2025.1526414. eCollection 2025.
7
Exploring the role of oral bacteria in oral cancer: a narrative review.探索口腔细菌在口腔癌中的作用：一篇叙述性综述。
Discov Oncol. 2025 Feb 26;16(1):242. doi: 10.1007/s12672-025-01998-2.
8
"Friends or foes": a new perspective of tumour metabolic transcriptional modification.“朋友还是敌人”：肿瘤代谢转录修饰的新视角
Cell Death Dis. 2025 Feb 17;16(1):106. doi: 10.1038/s41419-025-07429-y.
9
Exploring the various functions of PHD finger protein 20: beyond the unknown.探索PHD指蛋白20的多种功能：超越未知。
Toxicol Res. 2024 Nov 20;41(1):1-11. doi: 10.1007/s43188-024-00265-w. eCollection 2025 Jan.
10
Strategies to Overcome Intrinsic and Acquired Resistance to Chemoradiotherapy in Head and Neck Cancer.克服头颈癌对放化疗的内在和获得性耐药的策略
Cells. 2024 Dec 27;14(1):18. doi: 10.3390/cells14010018.
本文引用的文献
1
p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms.p53介导的肿瘤抑制：DNA损伤反应及其他机制
Cancers (Basel). 2019 Dec 9;11(12):1983. doi: 10.3390/cancers11121983.
2
Prostaglandin E Induces miR675-5p to Promote Colorectal Tumor Metastasis via Modulation of p53 Expression.前列腺素 E 通过调节 p53 表达诱导 miR675-5p 促进结直肠肿瘤转移。
Gastroenterology. 2020 Mar;158(4):971-984.e10. doi: 10.1053/j.gastro.2019.11.013. Epub 2019 Nov 14.
3
The Role of Non-coding RNAs in Oncology.非编码 RNA 在肿瘤学中的作用。
Cell. 2019 Nov 14;179(5):1033-1055. doi: 10.1016/j.cell.2019.10.017.
4
Down-regulation of JMJD5 suppresses metastasis and induces apoptosis in oral squamous cell carcinoma by regulating p53/NF-κB pathway.JMJD5 的下调通过调节 p53/NF-κB 通路抑制口腔鳞状细胞癌的转移并诱导细胞凋亡。
Biomed Pharmacother. 2019 Jan;109:1994-2004. doi: 10.1016/j.biopha.2018.07.144. Epub 2018 Nov 26.
5
Mutant p53 as a guardian of the cancer cell.突变型 p53 作为癌细胞的守护者。
Cell Death Differ. 2019 Jan;26(2):199-212. doi: 10.1038/s41418-018-0246-9. Epub 2018 Dec 11.
6
Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage.ATM 和 IFI16 介导非经典 DNA 感应衔接蛋白 STING 的激活，从而介导核 DNA 损伤后的 NF-κB 信号通路。
Mol Cell. 2018 Sep 6;71(5):745-760.e5. doi: 10.1016/j.molcel.2018.07.034.
7
Long non-coding RNA 00607 as a tumor suppressor by modulating NF-κB p65/p53 signaling axis in hepatocellular carcinoma.长链非编码 RNA 00607 通过调节肝癌中 NF-κB p65/p53 信号轴发挥抑癌作用。
Carcinogenesis. 2018 Dec 31;39(12):1438-1446. doi: 10.1093/carcin/bgy113.
8
Epithelial-to-mesenchymal transition in cancer: complexity and opportunities.癌症中的上皮-间充质转化：复杂性和机遇。
Front Med. 2018 Aug;12(4):361-373. doi: 10.1007/s11684-018-0656-6. Epub 2018 Jul 24.
9
Arsenic-induced apoptosis in the p53-proficient and p53-deficient cells through differential modulation of NFkB pathway.砷通过差异调节 NFkB 通路诱导 p53 功能正常和缺失细胞发生细胞凋亡。
Food Chem Toxicol. 2018 Aug;118:849-860. doi: 10.1016/j.fct.2018.06.053. Epub 2018 Jun 23.
10
Subunit-Specific Role of NF-κB in Cancer.核因子κB在癌症中的亚基特异性作用。
Biomedicines. 2018 Apr 17;6(2):44. doi: 10.3390/biomedicines6020044.
Zotero 插件