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First reported case of safe and efficacious use of tocilizumab for treatment of hyperinflammatory syndrome associated with COVID-19 in an allogeneic stem cell transplant patient.

作者信息

Fordham Nicholas, Baker Emma, Forton Daniel, Klammer Matthias, Patel Kamal, Qadir Dara, Reyal Yasmin, Willis Fenella, Koh Mickey B C

机构信息

Haematology Department St George's University Hospitals NHS Foundation Trust London UK.

St Catherine's College University of Oxford Oxford UK.

出版信息

EJHaem. 2020 Dec 8;2(1):143-146. doi: 10.1002/jha2.132. eCollection 2021 Feb.

Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4c8/9175733/435cbb63e967/JHA2-2-143-g001.jpg

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本文引用的文献

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Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients.
Natl Sci Rev. 2020 Jun;7(6):998-1002. doi: 10.1093/nsr/nwaa041. Epub 2020 Mar 13.
2
Effective treatment of severe COVID-19 patients with tocilizumab.
Proc Natl Acad Sci U S A. 2020 May 19;117(20):10970-10975. doi: 10.1073/pnas.2005615117. Epub 2020 Apr 29.
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COVID-19 pneumonia in a kidney transplant recipient successfully treated with tocilizumab and hydroxychloroquine.
Am J Transplant. 2020 Jul;20(7):1902-1906. doi: 10.1111/ajt.15935. Epub 2020 May 13.
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COVID-19: risk for cytokine targeting in chronic inflammatory diseases?
Nat Rev Immunol. 2020 May;20(5):271-272. doi: 10.1038/s41577-020-0312-7.
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Tocilizumab treatment in COVID-19: A single center experience.
J Med Virol. 2020 Jul;92(7):814-818. doi: 10.1002/jmv.25801. Epub 2020 Apr 15.
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First case of COVID-19 in a patient with multiple myeloma successfully treated with tocilizumab.
Blood Adv. 2020 Apr 14;4(7):1307-1310. doi: 10.1182/bloodadvances.2020001907.
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COVID-19: consider cytokine storm syndromes and immunosuppression.
Lancet. 2020 Mar 28;395(10229):1033-1034. doi: 10.1016/S0140-6736(20)30628-0. Epub 2020 Mar 16.
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Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China.
Intensive Care Med. 2020 May;46(5):846-848. doi: 10.1007/s00134-020-05991-x. Epub 2020 Mar 3.
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Clinical Characteristics of Coronavirus Disease 2019 in China.
N Engl J Med. 2020 Apr 30;382(18):1708-1720. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28.
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Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia.
J Thromb Haemost. 2020 Apr;18(4):844-847. doi: 10.1111/jth.14768. Epub 2020 Mar 13.

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